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| 骨代谢生化指标随年龄的变化及其临床意义 |
| Age related changes in biochemical markers of bone metabolism and their clinical significances |
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| DOI： |
| 中文关键词: 骨质疏松 骨代谢生化指标 骨转换 |
| 英文关键词:Osteoporosis Biochemical markers of bone metabolism Bone turnover |
| 基金项目:国家自然科学基金及北京市科委基金资助项目 |
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| 中文摘要: |
| 绝经后骨质琉格妇女。与年龄有关的摘要 本文收集了北京地区1928名不同年龄(0~87岁)健康人及5345例20余种疾病患者空腹尿及血，并对其骨代谢生化指标进行测定 结果表明：血清25羟基维生素D(25OHD)，碱性磷酸酶(ALP)，骨钙素(BGP)，甲状旁腺激素(PTH)，尿Ⅰ型胶原交联N末端酞与肌酐比值(NTX/Cr)及羟脯氨酸与肌酐此值(HOP/Cr)与年龄显著相关。血清 25OHD，BGP，尿NTX/Cr及HOP/Cr可用于预测骨量。1,25(OH)2D3，25OHD，NTX/Cr和HOP/Cr可用于区分绝经前与绝经后骨质疏松妇女。与年龄有关的骨丢失可能与 1,25(OH)2D3的降低、PTH的升高及肾功能减退有关；绝经后骨丢失与雌澈素缺乏有关。 |
| 英文摘要: |
| Fasting urine and blood samples were collected from 1928 healthy subjects aged 0~87 years and 5345 patients in Beijing and the biochemical markers were measured．The results indicated that
Serum 25 hydroxy vitamin D(25OHD)，alkaline phosphatase(ALP)，osteocalcin(BGP), parathyroid hormone(PTH) urine type Ⅰ collegen crosslinked N-telopeptides creatinine ratio(NTX/Cr) and hydroxyproline creatinine ratio(HOP/Cr)were significant correlates with age. Serum 25OHD,BGP,urine NTX/Cr and HOP/Cr could be used to predict bone mass．1,25(OH)2D3, 25OHD，NTX/Cr，HOP/Cr are able to discriminate between premenopausal and late osteoporotic patients. Age related bone loss may be due to a fail in 1，25(OH)2D3 and a rise in PTH and renal dysfunction．Postmenopausal bone loss could be due to estrogen deficiency. |
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