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| 25(OH)D等因素与45~85岁冈比亚妇女骨矿含量的关系 |
| The relationships between 25-hydroxyvitamin D and other factors with bone mineral content in Gambian women aged 45-85years |
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| DOI： |
| 中文关键词: 25(OH)D 骨矿含量 冈比亚妇女 |
| 英文关键词:25(OH )D BMC Cambian women |
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| 中文摘要: |
| 近年来有人多次提出，与年龄有关的维生素D内分泌系统的变化可能与骨丢失和骨质疏松
症有关。本文对108名 45~85岁冈比亚妇女维生素D水平与骨矿含量(BMC)关系进行了研究。研究对象选自于一项钙与骨代谢的课题。除维生素D水平与BMC的关系，对维生素D与肌肉强度，膳食钙对BMC的影响也做了探讨。结果表明：(1)与其他同类人群比较，冈比亚妇女血浆25(OH)D的水平较高，但随着年龄的增长及季节的变冷(12月~2月)而降低。(2)前臂，手腕及腰椎BMC随着年龄的增长而下降。(3)没有发现维生素D水平与BMC或肌肉强度有关，这种无关性不受骨与身体大小及血洋采取季节的影响。(4)冈比亚妇女食用富含钙食物频率很低；叶菜类食用量可能与手腕部BMC减少有关。这洋，在冈比亚人群中，本次研究不能证明维生素D在与年龄有关的骨丢失中起重要作用。 |
| 英文摘要: |
| Age related changes in the vitamin D endocrine system have frequently been implicated in the pathogenesis of bone loss and osteoporosis in recent years．In this study，a total of 108 Gambian
Women aged 45~85years were selected from a large study of investigating calcium and bone metabolism to investigate the relationship between vitamin D status and bone mineral content(BMC) in this rural African population．In addition，associations between vitamin D and muscle strength and the effect of calcium intake on BMC in these subjects were also examined．Analysis of data showed that (1)plasma 25-hydroxyvitamin D (25(OH)D) concentration of Gambian women were higher than observed in other studies in same age group but declined with age and were reduced in the cold season (Dec~Feb). (2)BMC ar shaft，wrist and spoin declined with age before and after bone and body size adjustments.(3) No relationships were found between vitamin D status and either BMC or muscle strength before and after adjustment for bone，body size and season of blood sampling．(4) Frequency of consumption of Ca-rich foods by Gambian women was low. A possible association was observed between regular leaf consumption and reduced BMC at the wrist．Thus，this study could not demonstrate that vitamin D plays a major role in age-related bone loss in a Gambian population. |
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