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| 伊班膦酸钠和阿仑膦酸钠对绝经后骨质疏松的干预研究 |
| Study of ibandronate and alendronate treatment for postmenopausal osteoporosis |
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| DOI： |
| 中文关键词: 骨质疏松 骨密度 伊班膦酸钠 阿仑膦酸钠 |
| 英文关键词:Osteoperosis Bone mineral density Ibandronate Alendronate |
| 基金项目: |
| 作者 | 单位 | | 包丽华,林华,李永军,陈新,钱程,徐兆强,程旭 | 包丽华,李永军,徐兆强,程旭(南京医科大学附属第一医院核医学科,南京,210029)
林华,陈新,钱程(南京鼓楼医院南京市代谢性骨病防治中心) |
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| 摘要点击次数: 2015 |
| 全文下载次数: 1482 |
| 中文摘要: |
| 目的 评价伊班膦酸钠和阿仑膦酸钠对绝经后骨质疏松骨量变化的作用.方法 64例年龄47～80岁,的绝经后骨质疏松妇女随机分为两组.Ⅰ组予以口服伊班膦酸钠150 mg,每月一次;Ⅱ组服用阿仑膦酸钠70 mg,每周一次,两组患者均每天服用钙剂0.6 g及维生素D 200 IU,治疗时间1年,治疗前后测量腰椎及髋部骨密度,评价伊班膦酸钠及阿仑磷酸钠对绝经后骨质疏松骨量变化的作用.结果 Ⅰ组治疗半年和1年后,患者腰椎骨量较治疗前分别增加了6.25%和9.64%,(P＜0.05),Ⅱ组治疗半年和1年后,患者腰椎骨量较治疗前分别增加了6.82%和11.4%,(P＜0.05),两组患者治疗1年后髋部骨量较治疗前也有所增加,以腰椎骨量增加最为明显.结论 两种双磷酸盐治疗绝经后骨质疏松均能显著改善患者骨量,临床疗效相近,但伊班膦酸钠临床耐受性较好. |
| 英文摘要: |
| Abstract：Objective To evaluate the effect of ibandronate and alendronate on bone mass in postmenopausal osteoporosis．Methods Sixty-four postmenopausal women aged 47 to 80 years old were randomly divided into two groups．Patients in Group 1 were administered oral ibandronate 150 mg per month.and patients in'Group Ⅱ were administered oral alendronate 70 mg per week.All patients received calcium 500 mg and vitamin D 200 IU daily for one year.Bone mineral density in the lumbar vertebra and the hip were examined before and after the treatment.Results BMDs in the lumbar spine of patients in Group l were increased by 6.25％and 9.64％，respectively,after a half-year and one-year treatment(P<0.05),and increased in patients in GroupⅡby 6.82％and 11.4％，espectively(P<0.05).In both group，BMDs of the hip also increased.However.the most obvious BMD increased occurred in the lumbar spine.Conclmion_Treatment with both bisphosphonates improved BMD in postmenopausal osteoporosis.Their clinical efficacies were similar.However.the clinical tolerance of ibandronate Was better． |
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