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| 罗格列酮对雌性大鼠骨代谢的影响 |
| Effects of rosiglitazone on the bone metabolism in female rats |
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| DOI： |
| 中文关键词: 罗格列酮 骨钙素 骨密度 雌二醇 |
| 英文关键词:Rosiglitazone Osteocalcin BMD Estradiol |
| 基金项目:山东省自然科学基金资助项目(基金编号ZR2009CL028)，山东省医药卫生科技发展计划(基金编号2009HW082) |
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| 中文摘要: |
| 目的 观察马来酸罗格列酮对雌性大鼠骨代谢的影响。方法 3月龄雌性Wistar大鼠40只随机分为4组，正常对照组(NC组)、低剂量(3mg.kg-1.d-1)罗格列酮组(Ros-1组)、中剂量(10mg.kg-1.d-1)罗格列酮组(Ros-2组)和高剂量(30mg.kg-1.d-1)罗格列酮组(Ros-3组)。每日定时按照每公斤体重6ml灌胃，NC组给予0.5％羧甲基纤维素钠溶液灌胃作为对照，干预12周。处死后，测定右侧股骨骨密度、血清骨代谢标记物和相关激素及细胞因子水平。结果 Ros-3组的股骨骨密度较其他三组显著降低，反映骨形成的血清骨钙素水平在Ros-2及Ros-3组显著降低，而其他骨代谢标记物无显著变化。各组的雌二醇、睾酮、瘦素水平无差异。Ros-3组IGF-1水平降低。各组炎症因子的水平无有意义的变化。结论 较大剂量的罗格列酮能减少正常雌性大鼠的骨形成，降低骨密度，对循环中雌二醇、睾酮及多数细胞因子无显著性影响。 |
| 英文摘要: |
| Abstract：0bjective To investigate the effects of rosiglitazone on the bone metabolism in female rats．Methods Forty 3-month-old female Wistar rats were randomly distributed into 4 groups，and were treated with rosiglitazone maleate at doses of 3,10,and 30mg kg-1.d-1(Ros-1，Ros-2，and Ros-3)，or 0.5％ carboxymethycellulose(NC)by gavage(6ml kg-1.d-1)for 12 weeks． Bone mineral density(BMD)of the fight femur，selum bone metabolic markers，and related hormones and eytokines were measured after the rats were killed．Results BMD of the femur in group Ros-3 decreasad significantly compared to that in 3 other groups．The serum levels of osteoealein decreased significantly in groups Ros-2 and Ros-3，but no change occurred in other bone metabolic markers．There was no difference in the 1evels of estradiol．testosterone，and leptin among the groups．The serum level of IGF-1 decreased in group Ros-3．No significant change occurred in the inflammatory factors among the groups．Conclusion Rosiglitazone at a higher dose decreases bone formation and BMD in the normal female rats．Rosiglitazone has no influence in serum levels of estradiol，testosterone，and most cytokines． |
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