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| 绝经后2型糖尿病患者血脂与骨代谢的关系 |
| The relationship between serum lipid level and bone metabolism in postmenopausal women with type 2 diabetes |
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| DOI： |
| 中文关键词: 血脂 骨质疏松 骨代谢 2型糖尿病 绝经后 |
| 英文关键词:Serum lipid Osteoporosis Bone metabolism Type 2 diabetes Postmenopausal |
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| 中文摘要: |
| 目的 探讨绝经后2型糖尿病患者血脂与骨代谢的相关性。方法 将300例绝经后2型糖尿病患者按T值分成骨质疏松组和非骨质疏松组；检测两组患者血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL.C)、低密度脂蛋白胆固醇(LDL-C)及骨代谢指标，分析血脂各成分与骨代谢之间的关系。结果 (1)绝经后2型糖尿病患者的HDL-C与OT、TrACP、uNTX／Cr存在正相关(r1=0.134，P1=0．020；r2=0．181，P2=0．002；r3=0．126，P3=0．030)，与BALP无相关性；TC与TrACP呈负相关(r=-0.153，P=0.038)，与OT、BALP、uNTX／Cr无相关性；TG、LDL-C与OT、BALP、TrACP、uNTX／Cr均无相关性。(2)在校正年龄、绝经年限和BMI影响因素后，HDL-C与TrACP、uNTX／Cr仍存在正相关(r1=0．160，P1=0.010；r2=0.125，P2=0.045)，而HDL-C与OT、TC与TrACP间的相关性失去统计学意义。结论 绝经后2型糖尿病患者的HDL．C与TrACP、uNTX／Cr存在正相关，与OT、BALP无相关性；而TC、TG、LDL-C与OT、BALP、TrACP、uNTX／Cr无明显相关性。 |
| 英文摘要: |
| Abstract：Objective To investigate the correlation between the serum lipid level and bone metabolism in postmenopausai women with type 2 diabetes．Methods Three hundred postmenopausai women with type 2 diabetes were divided into osteoporosis group(T≤-2.5)and non-osteoporosis group(T>-2.5) according to their T scores．The levels of serum total cholesterol(TC)，triglyceride(TG)，high density lipoprotein cholesterol(HDL-C)，low density lipoprotein cholesterol(LDL-C)，and bone metabolism markers in the patients were determined．The correlation between serum lipids and bone metabolism markers were analyzed．Results (1)In postmenopausal women with type 2 diabetes，the HDL-C level was positively correlated with OT，TrACP，and uNTX／Cr(r1=0.134，P1=0.020；r2=0.181，P2=0.002；r3 =0.126，P3=0.030)，but was not correlated with BALP．The TC level was negatively correlated with TrACP(r1=-0.153，P1=0.038)，but was not correlated with OT，BALP，and uNTX／Cr．There were no relationships among TG，LDL-C levels and OT，BALP，TrACP，and uNTX／Cr．(2)After adjustment for age，menopause age，and BMI，the associations between HDL-C and TrACP，uNTX／Cr remained statistically significant(r1=0.160，P1=0.010；r2=0.125，P2=0.045)，while the association between HDL-C and OT，and between TC and TrACP lost the statistical significance．Conclusions The HDL-C level showed positive correlations with TrACP and uNTX／Cr．no correlations with 0T and BALP in postmenopausal women with type 2 diabetes．There were no significant relationships among the TC，TG，LDL-C levels and OT，BALP，TrACP．and uNTX／Cr． |
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