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| 双氯芬酸二乙胺乳胶剂联合半导体激光治疗膝骨关节炎的临床研究 |
| Clinical study of the treatment of knee osteoarthritis with diclofcnac diethylamine emulsion and semiconductive laser |
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| DOI： |
| 中文关键词: 双氯芬酸二乙胺乳胶剂 半导体激光 联合治疗 膝骨关节炎 |
| 英文关键词:Dielofenae diethylamine emulsion Semieonductive laser Combination therapy Knee osteoarthritis |
| 基金项目: |
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| 摘要点击次数: 2029 |
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| 中文摘要: |
| 目的 评价双氯芬酸二乙胺乳胶剂联合半导体激光治疗膝骨关节炎(OA)的疗效和安全性。方法 334例符合美国风湿病学院(ACR)膝骨关节炎(OA)诊断标准的患者随机纳入试验组(双氯芬酸二乙胺乳胶剂联合半导体激光治疗组)和对照组(半导体激光治疗组)，治疗2周，随访1周。结果 经2周治疗，87％的试验组患者和76％的对照组患者评价疗效为有效和显著有效；医生的总体评价两组分别是86％和74％，两组间差异无统计学意义。试验期间两组不良反应的发生率分别为试验组7.3％、对照组10.8％，两组比较差异无统计学意义，不良反应以口服药物后出现轻度胃肠道反应为主，与外用药物和半导体激光治疗无明显相关。结论 双氯芬酸二乙胺乳胶剂与半导体激光联合应用治疗膝骨关节炎有明显的协同效应，能显著提高疗效，优于单一半导体激光疗法，该方法安全可靠，无明显副作用，值得推广。 |
| 英文摘要: |
| Abstract：Objective To evaluate the efficacy and safety of the treatment of knee osteoarthritis (OA)with dielofenac diethylamine emulsion and semiconductive laser．Methods Three hundred and thirty-four OA patients diagnosed according to ACR standard were randomly divided into experiment group(with diclofenae diethylamine emulsion and semieonduetive laser treatment)and control group(with semiconductive laser treatment)．The treatments continued for 2 weeks，and followed up for 1 week．Results The patients evaluated for effective and significantly effective were 87％in experiment group and 74％ in control group，respectively．after a 2-week treatment．The overall evaluation from the doctors was 86％ and 74％ for experiment group and control group，respectively．No statistical difference was found between the two groups．The rate of side effect was 7.3％in experiment group and 10.8％in control group，respectively，during the experimental period．No statistical difference was found between the two groups．Conclusion The treatment of OA with diclofenae diethylamine emulsion and semiconductive laser has significant co-effective response．It can improve treatment efficacy，and is better than semiconductive laser treatment alone．It is safe and has no obvious side effect．It is worth to propagate． |
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