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| 老年男性髋部骨折患者ERa基因多态性的病例对照研究 |
| Case-control study on ERa gene polymorphism in elderly males with hip fracture |
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| DOI： |
| 中文关键词: 雌激素受体 骨质疏松症 基因多态性 髋部骨折 男性 |
| 英文关键词:Estrogen receptor gene polymorphism Hip fracture Male |
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| 中文摘要: |
| 目的研究呼和浩特地区汉族老年男性髋部骨折患者雌激素受体基因多态性与骨质疏松症的 关系。方法收集老年男性髋部骨质疏松性骨折128例，按年龄配比选取汉族男性健康体检者128 名，进行病例对照研究。所有受试者均行骨密度检査，并进行雌激素受体基因多态性检测。结果骨 质疏松组雌激素受体Pvu E基因型PP、Pp及pp频率分别为7. 8% , 42. 2%和50. 0% ；对照组雌激素 受体Pvu E基因型PP、Pp及pp频率分别为13. 3% , 53. 9%和32. 8%，卡方检验提示，骨质疏松组和 对照组之间Pp，pp, PP三种基_的频率分布差异有显著性意义（P<0.05)。骨质疏松组雌激素受 体Xbal基因型XX、Xx及xx频率分别为4. 7% ’ 44. 5%和50. 8% ；对照组雌激素受体Pvu II基因型 XX、Xx及xx频率分别为3. 1%，39. 1%和57.8%，卡方检验提示，骨质疏松组和对照组之间XX、Xx 及xx三种基因型的频率分布差异无显著性意义（P>0.05)。结论雌激素受体基因型分布频率均 符合Hardy-Weinbag定律，呼和浩特地区老年男性ERa基因基因Pvu II酶切位点与原发性骨质疏松 症存在相关性。老年髋部骨折与雌激素受体基因多态性可能存在相关性。 |
| 英文摘要: |
| Objective To investigate the relationship between estrogen receptor (ER) gene polymorphism and osteoporosis in Han elderly males with hip fracture in Hohhot. Methods One hundred and twenty-eight elderly male patients with hip osteoporotic fracture were enrolled. One hundred and twenty-eight healthy people were enrolled and matched with age to conduct a case-control study. The bone mineral density and ER gene polymorphism measurement were performed to all subjects. Results The frequencies of ER PvuIIgenotype PP’Pp， and pp were 7. 8% ,42.2% , and 50.0% , respectively, in the osteoporosis group. The frequencies of ER Pvu I genotype PP, Pp, and pp were 13. 3% , 53. 9% , and 32. 8% , respectively, in the control group. ANOVA test indicated that the difference of ER PvuIIgenotype frequency between the osteoporosis group and the control group was statistically significant (P <0.05). The frequencies of ER Xbal genotype XX,Xx,and xx were 4.1%，44,5% , and 50. 8% , respectively, in the osteoporosis group. The frequencies of ER Xbal genotype XX，Xx，and xx were 3.1% ,39. 1% ’ and 57. 8% , respectively, in the control group. ANOVA test indicated that the difference of ER Xbal genotype frequency between the osteoporosis group and the control group was not statistically significant (P >0.05) Conclusion All frequency distribution of ER genotypes is fit for Hardy-Weinberg equilibrium. ER gene PvuERFLP is related to osteoporosis in Han elderly males in Hohhot area. Elderly hip fractures may be associated with ER gene polymorphism |
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