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| I型胶原吡啶交联末端肽在评价类风湿关节炎 患者病情活动和骨丢失中的临床意义 |
| The clinical value of serum C-terminal cross-linking teiopeptide of type I collagen in the assessment of disease activity and bone loss in patients with rheumatoid arthritis |
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| DOI： |
| 中文关键词: 类风湿关节炎；I型胶原吡啶交联末端肽；骨密度；DAS28 Sharp评分 |
| 英文关键词:The clinical value of serum C-terminal cross-linking teiopeptide of type I collagen in the assessment of disease activity and bone loss in patients with rheumatoid arthritis. |
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| 中文摘要: |
| 目的探讨I型胶原吡啶交联末端肽（I CTP)在评价类风湿关节炎（RA)病情活动和骨丢失 中的重要意义。方法对125例RA女性患者血清，采用酶联免疫吸附试验（ELISA)方法定量检测血 清骨代谢指标I CTP、I型胶原羧基末端肽（C区）p降解产物（p-CTX)、I型原胶原氨基端前肽 (PINP)的浓度，使用DAM8评估RA患者疾病活动指数，影像学sharp评分评估骨侵蚀与狭窄程度， 用双能X线吸收仪测定骨密度，并了解患者服用糖皮质激素情况。结果 RA疾病活动组I CTP值 明显高于ra疾病稳定组（i> |
| 英文摘要: |
| Objective To explore the clinical value of serum C-terminal cross-linking teiopeptide of type I collagen (ICTP) in the assessment of disease activity and bone loss in patients with rheumatoid arthritis (RA). Methods The serum concentration of ICTP, (3-CTX, and PINP of 125 female RA patients were measured using ELISA. The disease activity index was evaluated using disease activity score ( DAS28). The bone erosion and narrow level were evaluated using image sharp score. Bone mineral density ( BMD) was measured with dual-energy X absorptiometry ( DXA). The glucocorticoid condition was also acknowledged. Results ICTP in the RA active group were significantly higher than that in the RA stable group (P < 0. 01). The difference was also signiticant when the effect of glucocorticoid was excluded. Serum ICTP was positively associated with local bone erosion and narrow level and had no relationship with BMD. However, serum p-CTX was negatively associated with BMD, and had no relation with bone erosion and narrow level. Conclusion Serum ICTP is an effective assistant marker for the evaluation of RA activity and local bone loss. When ICTP obviously increases in clinic, anti-RA drug should be provided to prevent the subsequent joint bone disruption. |
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