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| 阿仑膦酸钠肠溶片对绝经后骨质疏松症 的疗效观察 |
| Efficacy observation of alendronate sodium enteric-coated tablet on postmenopausal osteoporosis |
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| DOI： |
| 中文关键词: 阿仑膦酸钠肠溶片 绝经 骨质疏松 |
| 英文关键词:Alendronate sodium enteric-coated tablets Postmenopausal Osteoporosis |
| 基金项目: |
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| 摘要点击次数: 1623 |
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| 中文摘要: |
| 观察阿仑膦酸钠（石家庄欧意药业有限公司生产的“固邦>’）治疗绝经后骨质疏松症的 临床疗效。方法选取80例绝经后骨质疏松症患者应用阿仑膦酸钠肠溶片治疗12个月，于治疗前 后测定肝肾功能、ALP、骨钙素、尿NTX及腰椎、股骨颈、Wards三角区骨密度。结果应用阿仑膦酸 钠肠溶片治疗12个月后患者骨密度较前升高（/><0.01),尿NTX(T值4. 499)及ALP(碱性磷酸酶） (T值9. 833)较治疗前降低（/><0.05)。结论阿仑膦酸钠肠溶片对绝经后骨质疏松症患者的治疗 是有效的，不良反应少,且依从性好。 |
| 英文摘要: |
| To observe the clinical efficacy of alendronate for the treatment of postmenopausal osteoporosis. Methods Eighty postmenopausal osteoporosis patients were chosen and treated with alendronate sodium enteric-coated tablets for 12 months. The liver and kidney function, ALP, osteocalcin, urinary NTX, and bone mineral density ( BMD) of the lumbar spine, femur neck, and Wards triangle were measured before and after the treatment. Results BMD increased after the 12-month treatment (P <0. 01) .However, urinary NTX (T =4. 499) and ALP (T = 9. 833) decreased after the 12-month treatment (P < 0.05) . Conclusion Alendronate sodium enteric coated tablets for the treatment of postmenopausal osteoporosis is effective with little adverse reaction and good compliance. |
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