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| 雷奈酸锶在模拟微重力环境对成骨细胞凋亡的影响 |
| The effects of strontium ranelate OH osteoblast apoptosis in simulated microgravity |
| 投稿时间：2012-12-14 |
| DOI： |
| 中文关键词: 微重力 雷奈酸锶 成骨细胞 凋亡 |
| 英文关键词:Microgravity Strontium ranelate Ostoblasts Apoptosis |
| 基金项目:国家教育部留学同国人员启动资金资助 |
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| 中文摘要: |
| 观察雷奈酸锶这种新型的抗骨质疏松药，在模拟微重力环境对成骨细胞凋亡的影响。方法
细胞凋亡是利用4．6-二氨基也-苯基吲哚所染细胞核形态的改变来辨认，利用旋转细胞培养系统模拟
微霞力环境。结果模拟微重力环境可以促进成骨细胞的凋亡，雷奈酸锶可以纠正模拟微重力环境
对成骨细胞凋亡的影响。结论在模拟微重力环境雷奈酸锶对成骨细胞生存具有保护作用，这为雷
奈酸锶治疗微蘑力环境骨丢失提供丁理论和实验证据。 |
| 英文摘要: |
| To investigate the role of strontium ranelate．the novel antiosteoporofic agent，in
regulating the apoptosis of osteoblasts under simulated microgmvity．Methods Apoptotic cells were
identified on the basis of nuclear morphology with 4，6-diamidino-2 phenylindole(DAPI)staining and
rotating cell culture system WB$used to simulate microgmVibtional effect．Results Simulated mierogravity
increased apoptosis of osteoblasts cells and this could be reversed by strontium mnelate treatment．
Conclusion Here we demonstrate that strontium ranelate plays a protective role in osteoblast survival in
simulated microgravity environment．This provides a theoretical and experimental evidence for the treatment
of microgravity—induced bone Iogs with strontium ranelate． |
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