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| CPC／PMMA双向骨水泥性能及生物相容生的初步研究 |
| Preliminary study OH properties and biocompatibility of CPC／PMMA dual-phase bone cement |
| 投稿时间：2012-01-12 |
| DOI： |
| 中文关键词: 聚甲基丙烯酸甲酯骨水泥 磷酸钙骨水泥 椎体成形术 椎体后凸成形术 |
| 英文关键词:Polymethylmethacrylate cement Calcium phesphme cement Vertebro plaety Kyphoplasty |
| 基金项目: |
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| 中文摘要: |
| 目的将聚甲基阿烯酸甲酯骨水泥(PMMA)与磷酸钙骨水泥(CPC)制成一种注射型混合骨
水泥，利用各自的特性，优势瓦补，从而使该混合骨水泥成为理想的椎体成形术及椎体后凸成形术填
充材料。方法实验材料为注射型PMMA骨水泥和注射型CPC骨水泥。首先将PMMA与CPC按质
量比1：2、1：1、2：l均匀混合，制成不同比例的混合骨水泥，然后将PMMA、CPC、混合骨水泥(1：2、1：1、
2：1)制成标准试件(直径6ram、高12mm)，最后对试件进行力学性能、凝固温度、凝同时间、电镜扫描、
x线衍射、动物肌肉内植入实验，初步评估混合骨水泥的性能及生物相容性。结果PMMA与CPC
在I：1比例混合时理化性能满意，其抗压强度较CPC提高约120％，凝固过程中的最高温度低于
45℃，凝固时间约12—14 rain，微观结构与CPC相似，孔径在100—300¨m之间分布最多(约70％)，
大部分孔与孔之间有10～201zm小孔冕通。动物肌肉内植入实验显示混合骨水泥(1：1)的组织相容
性满意。但降解速度缓慢。结论PMMA与CPC在I：1比例混合能有效克服单一材料缺点，优势互
补。从而使该混合骨水泥有望成为理想的椎体成形术及椎体后I九1成形术填充材料。 |
| 英文摘要: |
| To develop au injective mixture of bone cement made with polymethylmethacrylate
cement(PMMA)and calcium phosphate cement(CPC)and to become an ideal filling material for
vertebroplasty and kyphoplasty based on the advantages of each material．Methods The experimental
materials were injective bone eement PMMA and CPC．Firstly．the combined bone cement WaS made using
the different mass ratio of PMMA and CPC。l：2，1：1，or2：1．Secondly．the standard test pieces with 6mm
in diameter and 12ram in hight were made using the combined bone cement．Finally．a preliminary
evaluation of physical and chemical properIies of the mixed bone cement was carried out，i．e．。mechanical
property，solidification temperature，solidification time，electron microscope scanning，X-ray diffraction，
and animal muscle implantation experiment．Results The mixed bone cement(1：I)had better physical
and chemical properties than other proportions．Its compressive strength increased by about 1 20％higher
than that of CPC．The solidification temperature was lower than 45 oC．and solidification time was about 12-
14 rain．The microscopic structure of this mixed bone cement(1：1)was similar to that of CPC．Seventy
pereent of the total pares were between 100—300ltm and eyelet penetrations between the pores waft mainly 10-
20 um．The results of animal intramuscular implantation experiment demonstrated that the mixed bone cement
(I：i)had good biocompatibility，but the degeneration speed was slow．Conclusion The mixed bone
cement(1：1)can overcome the shortcomings of PMMA and CPC and have the advantage of each material．
So this mixed bone cement is au ideal filling material for vertebroplaaty and kyphoplasty． |
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