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| 福建畲族地区健康成人25羟维生素D及PTH水平与骨密度的关系 |
| The relationship between 25·hydroxyvitamin D and PTH and BMD in healthy people in She reglon in Fujian |
| 投稿时间：2012-01-19 |
| DOI： |
| 中文关键词: 维生素D 250HD 甲状旁腺激素 畲族 骨密度 |
| 英文关键词:Vitamin D 25 hydroxyvitamin D PTH She BMD |
| 基金项目:民政部十一五期间老年学研究骨质疏松项目(民人科教字、[2008]47．144) |
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| 中文摘要: |
| ：目的通过调查福建畲族地区健康人群血清25羟维生素D(250HD)、甲状旁腺激素(PTH)水
平及骨密度，分析福建畲族地区在冬季维生素D的状态并评价其与骨密度关系。方法于2010年
IO月至12月，调查634例畲族人群，其中男301例，女333例，年龄9-96岁，平均年龄50．14±16．07。
应用罗氏公司的器械和试剂，抽血检查血清25羟维生素D、PTH。同时应用美国Osdeometer Medi
Tech公司生产的DTX--200型骨密度仪检测前臂桡、尺骨远端三分之一BMD。根据血清250HD水
平分为<12nS／ml为严重缺乏，≥12rig／ml且<20nS／ml为缺乏，≥20nS／ml且<30ng／ml为相对不足，
≥30nS／ml为充足，并应用SPSSl6．0进行统计学分析。结果634例血清25羟维牛素D平均测定值
15．76±8．88n∥ml。血清250HD与性另0年龄无相关，与骨密度呈正相关，与PTH无相关。维生素D
严重缺乏231人占36．4％，缺乏的483人．占74．4％，相对不足的112人，占17．7％．充足的50人．占
7．9％，总的维生素D不足和缺乏占92．1％。结论福建畲族健康人群在冬季的维生素D普遍不足，
维生素D不足者骨密度较低，有统计学意义，与PTH没有相关。因此应重视维生素D的补充及生活
方式的改变。 |
| 英文摘要: |
| Objecfive To investigate the serum 25一hydroxyvitamin D(250HD)，parathyroid hormone
(町H)，and bone mineral density(BMD)of healthy people and to analyse the 250HD status in winter and
the relationship between 250HD and BMD in She region in Fujian．Methods Six hundred and thirty—four
healthy people，including 301 males and 333 females，aged from 9 to 96 years old with the mean age of
50．14±16．07 years old．were investigated．Serum 250HD and PTH were measured using the instruments
and regents from Roche．BMD of 1／3 of the forearm wag measured using U densitemetry(DTX-200，
Osdeometer Medi Tech)．The levels of serum 250HD were divided into severe deficiency as 250HD less
than 12 aS／m1．deficiency as 250HD more than 12 ns／ml and less than 20 ns／ml，relatively insufficiency a5
250HD more than 20 as／ml and less than 30 ns／ml，and sufficiency as 250HD more than 30 ns／m1．
Results The mean value of serum 250HD was 15．76±8．88 ns／m1．Serum 250HD had no relationship
with gender or age．It positively related to BMD and had no relation with PTH．The number of people with
severe deficiency，deficiency，relatively insufficiency，and sufficiency was 231(36．4％)，483(74．4％)，
112(17．7％)。and 50(7．9％)，respectively．The total 250HD deficiency and insufficiency accounted for
92．1％．Conclusion The insufficiency
of 250HD is common in She region in Fujian．BMD in people with
250HD insufficiency is relatively lower than that in normal people，and the difference is statistically
significant．The 250HD insufficiency has no relation with PTH．The supplement of vitamin D and the change
of life style should be focused． |
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