| Objective To explore the role of neural factors on the fracture healing through the comparative research between spinal cord injury (SCI) mice and control (CON) mice. Methods One hundred and twenty mice were made of unilateral femur fracture model, including 60 SCI mice and 60 CON mice. On 2, 4 and 8 weeks after the fracture, neovascularization was observed by vascular perfusion with Microfil in micro-CT, and serum VEGF was measured for learning vascular formation during fracture healing, and osteocalcin and alkaline phosphatase were measured for learning fracture healing, in 20 mice (10 of SCI, 10 of CON). The other 20 mice were under bone mineral density, micro-CT callus, and biomechanical property inspection. Results The angiogenesis, BMD, callus microarchitecture, and biomechanical properties of SCI mice were significantly weaker than those in control group, as well as serum VEGF, osteocalcin, and alkaline phosphatase. Conclusion SCI significantly inhibits fracture healing, reduces the amount of callus. Neural factor plays an important role in the fracture healing. |