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| 高甘油三酯及非诺贝特处理对老年雌性 大鼠骨密度的影响 |
| The effects of hypertriglyceridemia and fenofibrate treatment on bone mineral density in elderly |
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| DOI： |
| 中文关键词: 骨质疏松 甘油三酷 非诺贝特 |
| 英文关键词:Triglyceridemia 0steoporosis Fenofibrate |
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| 中文摘要: |
| 目的探讨高甘油三酷及非诺贝特对老年雌性大鼠骨密度的影响。方法老年雌性大鼠30 只随机分为3组：果糖组、非诺贝特组和普饲组，果糖组在普通饲料的基础上加人果糖，非诺贝特组在 果糖的基础上加人非诺贝特。12周后取血处死，测血甘油三酷水平，留右侧股骨和第3~6腰椎测骨 密度。结果果糖组的甘油三酷水平高于非诺贝特组和普饲组（孕孕均<0.01 );后两组间的甘油三酷 水平无统计学差异。果糖组的腰椎和股骨的骨密度均低于非诺贝特组和普饲组（孕孕均<0.01 );后两 组两个部位的骨密度均无统计学差异。结论高甘油三酷可以引起老年雌性大鼠骨质疏松，使用非 诺贝特可以防治此类骨质疏松。 |
| 英文摘要: |
| Objective To explore the effects of hypertrigiyceridemia and fenofibrate Lreatment on bone mineral density ( BMD ). Methods Elderly female faLs were divided into 3 groups， fructose group， fenofibrate group， and ordinary group according to their diet. All rats were sacrificed after 12 weeks. Blood triglyceride and BMD of the righL femur and the lumbar vertebra 3-6 were measured. Results Triglyceride level was higher in fructose group than in fenofibrate group and ordinary group (P < 0. 01 ). BMD of both sites in fructose group were lower than that in fenofibrate group and ordinary group (P < 0. 01 ). There was no difference of BMD between the laLer two groups. Conclusion HyperLriglyceridemia causes osteoporosis in elderly female faLs and fenofibrate can prevent hypertriglycerid-iia-induced osteoporosis. |
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