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| 定量超声对骨质疏松症诊断价值的Meta分析 |
| Quantitative ultrasound for the diagnosis of osteoporosis：a meta analysis |
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| DOI：10.3969/j.issn.1006.7108.2012.08.007 |
| 中文关键词: 骨质疏松症 定量超声 荟萃分析 |
| 英文关键词:Osteoporosis Quantitative ultrasound Meta analysis |
| 基金项目: |
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| 中文摘要: |
| 目的 系统评价定量超声应用于骨质疏松症诊断的临床价值。方法 荟萃分析，采用 Cochrane 系统评价的方法，检索 Medline( 1966~2011 年)、EMbase( 1966~2010 年）、Cochrane 图书馆 (2010年）及中国生物医学文献数据库CBM( 1979~2010年）有关采用定量超声诊断骨质疏松症的临床对照研究文献资料，按照纳入和排除标准限定研究对象，通过QUADAS评分量表进行文献质量评估后，使用Meta-disc 1.4统计软件进行Meta分析，计算汇总敏感性、特异性及其95%.可信区间，绘制汇总受试者操作特性曲线，综合评价定量超声应用于骨质疏松症诊断的临床价值。结果 共纳入使用定量超声诊断骨质疏松症的临床对照研究11项（共2219例），汇总敏感性为76% ( 95%CI,73%~79% )，汇总特异性为70%( 95% CI，68%~73%,)，汇总的曲线下面积为0.8232，Q值为0.7565。 结论 定量超声用于诊断骨质疏松症具有较高的敏感性且特异性尚可，但尚需更多大样本、多中心临床对照试验数据支持。 |
| 英文摘要: |
| Objective To evaluate the diagnostic value of quantitative ultrasound in osteoporosis. Methods The clinical literatures concerning quantitative ultrasound for diagnosis of osteoporosis compared to DXA were searched from Medline ( 1966 -2011 )，EM base ( 1966 -2010 )，the Cochrane Library ( 2010 ),and CBM ( 1979 -2010 ),according to Cochrane evaluation guidelines. The subjects were chosen according to the inclusive and exclusive criteria. Quality of literatures was evaluated by QUADAS table. The meta- analysis was performed by Meta-disc 1.4 statistical software. Results Only 11 literatures were included in this meta-analysis ( 2219 cases ). Summary sensitivity of quantitative ultrasound for the diagnosis of osteoporosis was 76% ( 95% CI，73%-76%. )，and the summary specificity was 70% ( 95% CI，68%-73% ). The area under SROC curve was 0.8232,and Q index was 0.7565. Conclusion Quantitative ultrasound has a relatively high sensitivity and specificity for the diagnosis of osteoporosis. However，large sample and multi-center clinical trails are required for further analysis. |
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