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| 雷奈酸锶在模拟微重力环境对成骨细胞分化功能的影响 |
| The effect of strontium ranelate on differentiation of osteoblasts in simulated microgravity |
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| DOI：10.3969/j.issn.1006.7108.2012.08.010 |
| 中文关键词: 微重力 雷奈酸锶 成骨细胞 分化 骨丢失 |
| 英文关键词:Microgravity Strontium ranelate Osteoblast Differentiation Bone loss |
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| 中文摘要: |
| 目的 观察雷奈酸锶这种新型的抗骨质疏松药，在模拟微重力环境对成骨细胞分化功能的影响。方法 利用碱性磷酸酶活性测定了解小鼠成骨样细胞MC3T3-E1的分化情况，利用旋转细胞培养系统模拟微重力环境。结果 模拟微重力环境可以抑制MC3T3-E1细胞分化功能，雷奈酸锶可以保护模拟微重力环境MC3T3-E1细胞的分化功能。结论 在模拟微重力环境雷奈酸锶对成骨细胞分化功能具有保护作用，这为雷奈酸锶治疗微重力环境骨丢失提供了理论和实验依据。 |
| 英文摘要: |
| Objective To investigate the effect of strontium ranelate，a novel anti-osteoporotic agent，on the differentiation of osteoblasts under simulated microgravity. Methods The differentiation of mouse osteoblasts MC3T3-E1 was measured with alkaline phosphatase activity. Microgravity was induced by rotating the cell culture system. Results Simulated microgravity inhibited the differentiation of MC3T3-E1 cells and this could be protected by strontium ranelate. Conclusion Strontium ranelate plays a protective role in the differentiation of osteoblasts in simulated microgravity. This provides a theoretical and expermiental evidence for strontium ranelate to treat microgravity-induced bone loss. |
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