中国骨质疏松杂志

834 例女性 CTX-1、TRACP、BGP、BALP 水平与BMD相关性研究

Study on the relevance of CTX-1，TRACP，BGP，BACP levels with BMD in 834 cases of female

DOI：

英文关键词:indicator of bone metabolism BMD relevance

基金项目:

作者	单位
张萌萌	吉林大学第四医院
李亚刚	吉林大学第四医院
高远	吉林大学第四医院
马倩倩	吉林大学第四医院
毛未贤	吉林大学第四医院

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中文摘要:

目的研究I型胶原C端肽（CTX-1 )、抗酒石酸酸性磷酸酶（TRACP)、骨钙素（BGP)、骨特异性碱性磷酸酶（BALP)与股骨颈骨密度（BMD)的相关关系。方法采用美国Thermo公司酶标免疫分析仪检测CTX-1、TRACP、BGP、BALP，采用美国Hologic公司生产的Discovery WA型骨密度仪检测股骨颈BMD。将834例受试者检测结果按5岁为一年龄段分组，应用SPSSS 13. 0分析软件进行统计分析。结果 35 ~45岁年龄段CTX-1、TRACP与BMD呈负相关，而BGP、BALP与BMD呈正相关；50 ~ 60岁年龄段BGP、BALP明显升高，CTX-1、TRACP、BGP、BALP均与BMD呈负相关；65岁以后BGP、 BALP开始下降，BGP、BALP与骨密度呈正相关，CTX-1、TRACP与骨密度呈负相关。结论 CTX-1、 TRACP、BGP、BALP是监测骨代谢水平及骨质疏松诊断、鉴别诊断的重要技术手段。

英文摘要:

Objective To study the relevance of CTX-1，TRACP，BGP，BALP with the neck BMD in female. Methods Enzyme immunoassay analyzer of Thermo company to detect CTX-1， TRACP， BGP， BALP， and BMD was measured by Discovery-WA-type bone mineral density detector of the United States Hologic company. To divide the results of 834 objects into several groups according to the standard of 5-year- old age as a group， SPSS 13.0 software was applicated for statistical analysis. Results The CTX-1， TRACP had negative relevance with BMD in 35 -45 age group and BGP， BALP had positive relevance with BMD in 35 -45 age group. The BGP， BALP increased significantly in 50 -60 age group， and CTX - 1、 TRACP、BGP、BALP had negative relevance with BMD in 50 -60 age group. BGP，BALPbegan to decline and had positive relevance with BMD after the age of 65，and CTX - 1，TRACP had negative relevance with BMD after the age of 65. Conclusion CTX-1，TRACP，BGP，BALP were the important technical means for monitoring the level of bone metabolism and the diagnosis and differential diagnosis of osteoporosis.

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