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| 去势手术联合激素注射对绵羊腰椎生物 力学性能的作用 |
| The effect of ovariectomy combined with methylprednisolone injection on biomechanical properties of sheep lumbar vertebrae |
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| DOI： |
| 中文关键词: 骨质疏松 脊柱 卵巢切除术 甲基强的松龙 生物力学实验 |
| 英文关键词:Osteoporosis Spine Ovariectomy Methylprednisolone Biomechanical test |
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| 中文摘要: |
| 目的评价去势手术联合激素注射对绵羊腰椎生物力学性能的作用。方法健康成年绵羊 10只，随机分为假手术组（n =5 )和实验组（n = 5 )。假手术组仅显露双侧卵巢；实验组行双侧卵巢切 除术(ovariectomy, OVX)，且术后1月开始肌肉注射甲基强的松龙（0.45 mg/kg/d ) 10月。测量术前 和术后1年绵羊腰椎的骨密度（BMD)，通过压缩实验和轴向拔出实验来评价术后1年椎体的生物力 学性能。结果术后1年实验组绵羊腰椎的BMD显著下降（P<0. 05 )，平均下降T5.1%。实验组的 最大压缩应力和能量吸收值均显著低于假手术组，差异均具有统计学意义（P<0. 05 )；实验组的最大 轴向拔除力和能量吸收值均显著低于假手术组，差异均具有统计学意义（P<0.05 )。结论去势手 术联合激素注射的方法可以显著降低绵羊腰椎的BMD，显著降低绵羊腰椎自身的生物力学强度和对 椎弓根螺钉的把持力。该方法可用于建立适合脊柱及内固定稳定性研究的骨质疏松动物脊柱模型。 |
| 英文摘要: |
| Objective To evaluate the effect of ovariectomy combined with methylprednisolone injection on biomechanical properties of sheep lumbar vertebrae. Methods Ten adult sheep were divided into sham group ( n = 5 ) and experiment group ( n = 5 ) randomly. Both ovaries were just exposed in sham group. In experiment group， bilateral ovariectomy ( OVX) was performed， and 1 month later methylprednisolone (0.45 mg/Kg/d) were injected intramuscularly for 10 months. Bone mineral density ( BMD) of all sheep lumbar vertebrae was examined before and 1 year after surgery. Compression test and axial pullout test were performed to evaluate biomechanical properties of sheep lumbar vertebrae 1 year after surgery. Results BMD in experiment group had a mean decrease by 25. 7% after 1 year of the surgery, which was significant (P < 0. 05 ) . The ultimate compression load and energy to failure in experiment group were significantly lower than those in sham group ( P <0. 05 ). The maximum pullout strength and energy to failure in experiment group were significantly lower than those in sham group (P < 0. 05). Conclusion The method of ovariectomy combined with methylprednisolone injection can significantly decrease BMD and biomechanical properties of sheep lumbar vertebrae. This method can be used to establish osteoporotic spine model for studies on stability and inter fixation of the spine. |
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