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| 绝经后妇女骨代谢生化指标与骨密度相关性研究 |
| The study of the correlation between bone mineral density and biochemical factors of bone metabolism in postmenopausal women |
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| 中文关键词: 绝经女性 骨密度 骨质疏松 骨钙素 抗酒石酸酸性磷酸酶 血清碱性磷酸酶 |
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| 摘要点击次数: 1363 |
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| 中文摘要: |
| 目的探讨绝经女性骨密度与骨代谢生化指标血清抗酒石酸酸性磷酸酶5b的关系。方法 选取我科2007 -2009年人院的绝经女性115例，采用DPX2L型双能X线骨密度检测仪，测定腰椎 (L2 ~L4)及股骨上端[包括股骨颈（NECK)、华氏三角（Ward)及股骨粗隆（TROCH)]的骨密度 (BMD)值；根据Tscore值将人选者分为骨量正常组（48例)和骨质疏松组（67例）。并选未绝经女性 30例，骨密度检查正常者为对照组，采用酶联免疫法测定各组血清骨特异性碱性磷酸酶（ALP)、血清 骨钙素（BGP)、血清抗酒石酸酸性磷酸酶（TRAP-5b)的浓度，并比较三组骨代谢生化指标的变化，并 对BMD与各项骨代谢指标进行相关性分析。结果绝经女性骨质疏松组各部位BMD值均低于骨量 正常组(P<0. 05)；骨质疏松组血中ALP、BGP、TRAP-5b浓度均显著高于骨量正常组（P <0. 05 )，骨 量正常组血清ALP、BGP、TRAP-5b浓度显著高于对照组，差异有统计学意义（P < 0. 05 )。对照组各部 位的骨密度值与骨代谢生化指标无明显相关性（P>0.05)，在绝经女性骨质疏松组中，ALP和TRAP- 5b与腰椎（L2 ~L4)及股骨颈部位的BMD有一定的关系，呈负相关（r分别为-0. 248、- 0. 364、- 0.434、-0.386 )。结论绝经女性骨质疏松为高转换型，血清ALP、BGP、TRAP-5b浓度变化可反映 骨代谢活动，绝经女性BMD的降低与骨转换率升高有关。检测代谢指标有助于早期防治骨质疏松症 (OP)。 |
| 英文摘要: |
| Objective To investigate the relationship between bone mineral density ( BMD) and the biochemical factor of bone metabolism，serum tartrate -resistant acid phosphatase 5 b ( TRAP-5b)， in postmenopausal women. Methods One hundred and fifteen postmenopausal women who were hospitalized in our department from 2007 to 2009 were enrolled. BMD of the lumbar vertebrae ( L2-L4 )， the proximal femur (including thefemoral neck， the Wards triangular area, and TROCH) was tested using dual X- absorptiometry ( DPX2L) . All the subjects were divided into 2 groups，the normal bone mass group and the osteoporotic group according to T score. Thirty pre-menopausal women were selected， and people among them with normal BMD were selected as normal control group. The concentrations of serum alkaline phosphatase ( ALP)， osteocalcin ( BGP)， and TRAP-5b were examined using ELISA method. The changes of biochemical factors of bone metabolism among 3 groups were compared，and the correlation between BMD and each biochemical factor of bone metabolism was analyzed. Results BMD of each location in the osteoporotic group was significantly lower than that in the normal bone mass group ( P <0. 05 ). The concentrations of ALP， BGP， and TRAP-5b in the osteoporotic group were significantly higher than those in the normal bone mass group ( P < 0. 05 ). The concentrations of ALP， BGP， and TRAP-5b in the normal bone mass group were higher than those in the normal control group，and the difference was significant ( P < |
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