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| 25-(OH)VD与2型糖尿病患者的糖尿病肾病相关性研究 |
| The correlational study of 25-(OH) VD and diabetic nephropathy in type 2 diabetic patients |
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| DOI：10.3969/j.issn.1006-7108.2012.10.001 |
| 中文关键词: 25-(OH)VD 2型糖尿病 尿微量白蛋白 |
| 英文关键词:25-(OH) VD Type 2 diabetes Albuminuria |
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| 中文摘要: |
| 目的 探讨25-(OH)VD与2型糖尿病患者的糖尿病肾病相关性。方法 收集937例未接受维生素D补充治疗的2型糖尿病患者，测定各临床指标以分析糖尿病肾病的相关因素。结果 与正常尿微量白蛋白组患者相比，微量或大量尿白蛋白组患者的25-(OH)VD 水平较低且具有显著统计学差异。相关性分析显示,用性别和BMI作为校正指数，年龄、糖尿病病程、高血压病程、收缩压、糖化血红蛋白、肌酐、尿素氮与尿微量白蛋白呈正相关，而25-(OH)VD 水平与尿微量白蛋白呈负相关。结论 25-(OH)VD 水平与2型糖尿病患者的尿微量白蛋白呈显著负相关。 |
| 英文摘要: |
| Objective To investigate the correlation between 25-(OH) VD and diabetic nephropathy in type 2 diabetic patients. Methods A total of 937 patients with type 2 diabetes without vitamin D supplement therapy were included. Clinical indicators were tested in order to analyze the related factors of diabetic nephropathy. Results Compared with the patients in normal group with normal albuminuria, patients with micro- or macro albuminuria showed a lower level of 25-(OH) VD, and the difference was significant. By using gender and body mass index (BMI) as correction indexes, correlation analysis revealed that age, duration of diabetes and hypertension, systolic blood pressure (SBP), glycated hemoglobin (HbA1c), creatinine, and blood urea nitrogen (BUN) were positively correlated with albuminuria. While the level of 25-(OH) VD was negatively correlated with albuminuria. Conclusion The level of 25-(OH) VD is significantly negatively correlated with albuminuria in type 2 diabetic patients. |
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