| Objective By comparing the changes of bone mineral density (BMD) and bone metabolic markers before and after the treatment with Bushen Zhuanggu Granules for half a year, and comparing the effect among Bushen Zhuanggu Granules group, alendronate sodium group, and Caltrate D group, the clinical efficacy of Bushen Zhuanggu Granules on low bone mass, osteoporosis, and bone metabolism in senile male patients was observed. Methods The serum levels of PINP, β-Crosslaps, and N-MID were tested using electrochemiluminescence immunoassay. BMD of different locations was measured using Lunar Prodigy dual energy X ray (DXA, GE Co., USA). All the subjects were divided into 3 groups according to the time they came to the hospital. Patients in Bushen Zhuanggu Granules group were given Bushen Zhuanggu Granules + Caltrate D. Patients in alendronate sodium group were given alendronate sodium tablets + Caltrate D. And patients in Caltrate D group were given Caltrate D only. Results After a 6-month treatment, the serum levels of PINP, β-Crosslaps, and N-MID in Bushen Zhuanggu Granules group decreased significantly. BMD of the femoral neck, Ward's triangle, and the left femur increased significantly. Compared with Caltrate D group, Bushen Zhuanggu Granules group showed a better efficacy on improving bone metabolism and increasing BMD in elderly men, while compared with alendronate sodium treatment, Bushen Zhuanggu Granules showed a similar efficacy. Conclusion Bushen Zhuanggu Granules is safe and effective for the treatment of senile male patients with low bone mass and osteoporosis by increasing their bone mass and improving their bone metabolism. |