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| 2 型糖尿病患者骨病变与视网膜病变程度相关性的临床分析 |
| Clinical analysis of the correlation between bone lesion and retinopathy in patients with type 2diabetes |
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| DOI：10.3969/j.issn.1006-7108.2012.10.008 |
| 中文关键词: 2 型糖尿病 视网膜病变 骨质疏松 钙磷乘积 |
| 英文关键词:Type 2 diabetes mellitus Retinopathy Osteoporosis Calcium phosphorus product |
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| 中文摘要: |
| 目的 探讨2 型糖尿病患者钙磷代谢指标?骨密度与视网膜病变程度的相关性? 方法 选择2 型糖尿病患者共 169 例,以有无视网膜病变和视网膜病变程度分为3 组,即无视网膜病变组(A组)50 例?背景性视网膜病变组(B组)58 例和增殖性视网膜病变组(C组)61 例? 用生化比色法测血清钙?磷?24h尿钙定量,计算血钙磷乘积,酶免法测血甲状旁腺激素水平,骨定量CT测骨密度? 结果A组与B组相比较各指标均无显著性差异;C组与A组或B组比较,血清钙?磷?甲状旁腺激素无显著性差异,但血钙磷乘积显著降低,24h尿钙显著减少,骨密度亦显著降低? 结论 2 型糖尿病微血管病变严重程度与钙磷代谢和骨量多少相关? |
| 英文摘要: |
| Objective To investigate the relationship among calcium and phosphorus metabolism , bone mineral density, and retinopathy in patients with type 2 diabetes. Methods One hundred and sixty-nine patients with type 2 diabetes were selected. hey were divided into 3 groups, non-retinopathy group (group A) with 50 cases, background retinopathy group (group B) with 58 cases, and proliferative retinopathy group (group C) with 61 cases. Serum calcium, phosphorus, 24-hour urinary calcium were measured using biochemical assay. Blood calcium-phosphate product was calculated. Blood parathyroid hormone was measured using ELISA method. Bone mineral density was measured using quantitative CT .Results The parameters between group A and B were not significantly different .Serum calcium, phosphorus, parathyroid hormone were not significantly different between group C and group A or B , but a significant reduction in blood calcium-phosphate product, 24 hour urinary calcium, and bone mineral density were found in group C. Conclusion The severity of microvascular disease and calcium and phosphorus metabolism is somehow correlated in patients with type 2 diabetes. |
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