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| 炎症性肠病诱发骨质疏松症发病机制的研究进展 |
| Research progress on pathogenesis of inflammatory bowel disease ( IBD )-induced osteoporosis |
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| DOI：10. 3969/j. issn. 1006-7108. 2012. 12. 025 |
| 中文关键词: 骨质疏松症 炎症性肠病 炎症因子 |
| 英文关键词:Osteoporosis Inflammatory bowel disease Inflammatory factor |
| 基金项目:国家自然科学基金（81170354 );广东省科技计划项 目(2011B031800195 ) |
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| 中文摘要: |
| 骨质疏松症是炎症性肠病的晚期并发症之一。随着炎症性肠病的发生和发展，骨质疏松症的发病率逐渐增多。多种因素参与了炎症性肠病诱发骨量减少、骨质疏松，其中包括糖皮质激素、吸收不良及细胞因子等。因此，本文针对炎症性肠病诱发骨质疏松症的机制进行综述。 |
| 英文摘要: |
| Decreased bone mineral density and osteoporosis is a frequent finding in patients with inflammatory bowel disease ( IBD ). With the development of IBD， the incidence of osteoporosis is increasing. Many risk factors are involved in this process， including Malabsorption of vitamin D， calcium， vitamin K and other nutrients，steroid use and increase of inflammatory cytokines. In this review， we discuss the molecular pathways involved in the process of osteoporosis in IBD patients. |
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