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| 中国丹东地区2型糖尿病患者骨质疏松症相关危险因素分析 |
| Correlation analysis of osteoporosis-related risk factors in patients with type 2 diabetes in Dandong area |
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| DOI： |
| 中文关键词: 2型糖尿病 骨质疏松症 骨密度 危险因素 |
| 英文关键词: |
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| 中文摘要: |
| 目的分析丹东地区2型糖尿病（T2DM)患者骨质疏松症（0P)情况及骨质疏松症相关危险因 素。方法测定232例T2DM患者腰椎及股骨颈（晕藻糟噪）骨密度（BMD )，根据1998年WHO制定的 0P诊断标准把T2DM患者分为OP组与非OP组，比较两组生化指标、BMD差异，并进行相关性分析。结果1. T2DM患者中0P组与非0P组之间生化资料比较示0P组低密度脂蛋白（LDL-C )较非0P 组明显高，存在显著性差异（孕<0.05 )。2.0P组与非0P组腰椎（L1-4 )BMD比较示两组之间无显著 性差异（P >0. 05 )；0P组的总体、男性及女性的平均股骨颈（Neck )BMD明显低于非0P组，两组之间 存在显著性差异（P <0.05 )。3. T2DM患者中0P组65例，总体发病率28.0%.( 65/232 )，其中男性8 例，男性发病率12.5%( 8/64 );女性57例，女性发病率33.9%( 57/168 )，男女0P发病率比较，存在 显著性差异(f越10.552，<0. 05 )。4. LogisLic回归分析示：T2DM患者中女性、有微血管并发症（糖 尿病肾病或/和糖尿病视网膜病变）、有高血压、血清钙离子低、低体重指数与0P发生相关（P <0.05 )。结论1.丹东地区住院T2DM患者的0P发病率28.0%.，明显高于正常人群，且女性发病率 高于男性。2.丹东地区T2DM患者中女性、有微血管并发症（糖尿病肾病或/和糖尿病视网膜病变）、有高血压、血清钙离子低、低体重指数与0P发生相关。 |
| 英文摘要: |
| Objective To investigate the incidence of osteoporosis ( 0P ) in patients with type 2 diabetes (T2DM )， and to analyze the risk factors of OP in Dandong area. Methods Bone mineral density (BMD ) of the lumbar vertebrae and the feioral neck in 232 patients with T2DM was tested. All the patients were divided into two groups: 0P Group and non-OP Group， according to the 1998 WHO sLandard of OP diagnosis. Biochemical index and BMD of patients in both groups were compared and analyzed for corre ation. Results The comparison of biochemical index of T2DM paLienLs in boLh OP Group and non-OP Group showed that lDL-C in OP Group was higher than that in non-OP Group， and the diilerence was significant ( P < 0. 05 ). BMD of the lumbar vertebrae in both groups had no significant difference ( P >0. 05 ). The average BMD of the femoral neck of all male and female patients in OP Group was significanty lower than that in non-OP Group ( P < 0. 05 ). The OP Group had 65 patients，and Lhe incidence of OP in all T2DM paLients was 28. 0% .Among all these patients， 8 wer^ male w i th an incidence of 12. 5% ( 8/64 )， and 57 were female with an incidence of 33. 9% ( 57/168 ). The incidence of OP in females and males had significant difference (X2= 10. 552， P < 0. 05 ). togistic regression analysis showed that female gender， micro-vascular compiicaLions ( DN or DR )， hyperLension， low serum calcium， and low BMI were correlaTed |
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