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| 唑来膦酸治疗老年原发性骨质疏松症的临床安全性观察 |
| Clinical safety observation of zoledronic acid treatment for senile primary osteoporosis |
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| DOI： |
| 中文关键词: 唑来膦酸 原发性骨质疏松 老年 双膦酸盐 |
| 英文关键词:Zoledronic acid Primary osLeoporosis Senile Bisphosphonates |
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| 中文摘要: |
| 目的探讨临床应用唑来膦酸静脉滴注治疗老年原发性骨质疏松症的安全性和依从性。方法 观察首次静脉滴注唑来膦酸治疗50例原发性骨质疏松症患者的一般情况和副反应，询问患者是否 愿意接受第二次治疗。结果所有患者在滴注过程中均无严重不良反应发生，但24%_患者在输注后 3凿内出现了急性一过性不良反应，包括发热、关节痛、肌痛、流感样症状、头痛等，绝大多数患者同意 继续使用。结论唑来膦酸治疗原发性骨质疏松症安全性较高，依从性好，是一种较理想的治疗新选 择，其疗效有待于长期随访 |
| 英文摘要: |
| Objective To investigate the safety and compliance of zoledronic acide which was clinically used through intravenous injection，for the treatment of senile primary osteoporosis. Methods A total of 50 patients with primary osteoporosis who were treated with zoledronic acid intravenously for the first-tmie were enrolled. General condition and adverse reaction of all the patients were observed. Their willing about whether to receive the 2nd treatmenL or not was inquired. Resuits None of 50 patients had severe adverse reaction during the process of intravenous injection. Whereas 24%' patients had acute and temporary adverse reaction， including fever， joint pain，myosalgia， influenza-like symptom， and headache in Lhe first 3 days afLer intravenously injection. Most paLients agreed Lo use zoledronic acid for the treatment continually. Conclusion The safety of zoledronic acid for the treatment of primary osteoporosis is high， and the compliance is good. The treatment is a new ideal choice， but the clinical effect needs long-term follow-up. |
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