中国骨质疏松杂志

含高钙和维生素D的强化奶能有效提高健康的绝经后的中国女性体内的维生素D水平并减少骨吸收

High-calcium and vitamin D fortified milk is effective on improving vitamin D status and reducing bone resorption in Chinese healthy postmenopausal women

DOI：10.3969/j.issn.1006-7108.2013.02.003

中文关键词: 中国绝经后的女性含钙强化奶骨标志物CTX 维生素D水平 25（OH）维生素D3 中国

英文关键词:Chinese postmenopausal women Calcium fortified milk Bone markers CTX Vitamin D status 25-(OH) vitamin D3 China

基金项目:

作者

单位

Marlena C Kruger PengCheng Ha Joanne M Todd Barbara Kuhn-Sherlock Linda M Schollum Jiliang Ma George Qin Edith Lau

新西兰北帕默斯顿梅西大学（Marlena C Kruger）；中国北京基础研究和临床中心（PengCheng Ha、George Qin）；新西兰奥克兰恒天然品牌有限公司（Joanne M Todd）；新西兰北帕默斯顿恒天然研究中心（Barbara Kuhn-Sherlock、Linda M Schollum）；北京友谊医院（Jiliang Ma）；香港卫生和医疗研究中心，基础研究和临床中心（Edith Lau）

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中文摘要:

目的钙摄入水平低以及体内维生素D不足是导致亚洲女性罹患骨质疏松的危险因素。此项研究的目的是评估高钙维生素D强化牛奶（HCM）对健康的中国绝经后妇女的体内维生素D状态和骨吸收标志物进行干预的影响。方法本试验对象为55岁以上，绝经至少5年的女性。共有124名女性进行了总体健康状况和骨密度检查筛选。63名女性被随机分为对照组和试验组，试验组在12w内每日饮用两次高钙/维生素D强化奶（含900mg钙、96mg镁、2.4mg锌和6.4μg维生素D）。2组分别在试验开始、试验2w、8w和12w时测量血矿物质、25（OH）维生素D3和Ⅰ型胶原C端肽(CTX)水平。结果对照组女性平均年龄为63±4.6岁，高钙强化奶（HCM）组女性平均年龄为62±3.8岁。所测得的每日钙摄入量的基线值为HCM组260~482mg，对照组为252~692mg。12w后HCM组的平均身体质量指数（BMI）显著降低（P<0.05）。HCM组的血25（OH）维生素D3水平显著提高（33.13~39.49 nmol/L），而对照组则维持不变（29.27~28.21nmol/L）。HCM组的血CTX水平在0w和2w之间下降了25%，并保持不变直至第12w。从第2w开始HCM组和对照组相比血CTX水平就出现了显著差异（P<0.001）。结论通过饮用含高钙和维生素D的强化奶（HCM），在2至4w内能显著提高中国绝经妇女体内维生素D水平，并减少骨吸收破坏。如果长期持续地饮用含高钙和维生素D的强化奶（HCM），能减少骨吸收和骨量丢失的风险，从而减少患骨质疏松和由此引起骨折的风险。

英文摘要:

Background Low calcium intake and insufficient vitamin D status are risk factors for osteoporosis amongst Asian women. The purpose of this study was to evaluate the effect of high-calcium and vitamin D fortified milk (HCM) intervention on vitamin D status and bone resorption markers in Chinese healthy postmenopausal women. Methods Women over 55 years old, and with at least a 5-year post-menopausal period were recruited. A total of 124 women received the screening of general health status and bone mineral density (BMD). Sixty-three women were randomly divided into control group and study group. Women in study group drank HCM (containing 900mg calcium, 96mg magnesium, 2.4mg zinc, and 6.4μg vitamin D) twice per day for 12 weeks. Women in control group had a control drink twice per day for 12 weeks. Blood minerals, 25-(OH) vitaminD3, and C-telopeptide of Type I collagen l (CTX) were tested at baseline, 2, 8 and 12 weeks after the supplementation. Results The average age of women in control group and study group was 63± 4.6 years old and 62± 3.8 years old, respectively. Daily calcium intake at baseline ranged from 260mg to 482mg in HCM group and 252mg to 692mg in control group, respectively. Mean body mass index (BMI) of women in HCM group had significantly decreased after 12 weeks (P<0.05). Serum levels of 25-(OH) vitamin D3 of women in HCM group had improved significantly (from 33.13 to 39.49nmol/L), while the levels in control group remained unchanged (from 29.27 to 28.21nmol/L). Blood concentrations of CTX in HCM group had reduced by 25% between the 1st weeks and 2nd week, remaining unchanged until the 12th week. Significant difference of blood CTX between control group and study group was observed from the 2nd week (P<0.001). Conclusions Through drinking HCM, serum levels of vitamin D in Chinese postmenopausal women improve significantly within 2-4 weeks. Bone resorption decreases at the same time. Long term supplementation of HCM can reduce the risk of bone resorption and bone loss, thereby reducing the risk of osteoporosis and related fractures.

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