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| 骨髓间充质干细胞移植对去卵巢骨质疏松骨量影响的实验研究 |
| Effect of transplantation of bone marrow mesenchymal stem cells on bone mass in ovariectomized osteoporotic rats |
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| DOI：10.3969/j.issn.1006-7108.2013.02.007 |
| 中文关键词: 骨髓间充质干细胞 骨质疏松 |
| 英文关键词:Bone marrow mesenchymal stem cells Osteoporosis |
| 基金项目:全军十一?五课题（06MA303） |
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| 中文摘要: |
| 目的 探索骨髓间充质干细胞（BMSCs）移植对去卵巢骨质疏松大鼠骨密度的影响。方法 雌性SD大鼠随机分为空白对照组（A组）、模型组（B组）、细胞治疗组（C组）、雷诺昔芬药物治疗组（D组）。通过去卵巢建模成功后，C组通过尾静脉移植BMSCs，D组口服雷诺昔芬抗骨质疏松药物。结果 与A组相比，B组腰椎和股骨骨密度均明显降低（P＜0.01）。MSCs治疗后，C 组中的骨密度得到明显改善，并与B组比较具有统计学差异（P＜0.01），亦优于D组。结论 BMSCs可以有效改善去卵巢大鼠骨质，这为绝经后骨质疏松的治疗提供了一种新的方法，为进一步临床应用提供了实验支持。 |
| 英文摘要: |
| Objective To investigate the effect of transplantation of bone marrow mesenchymal stem cells (BMSCs) on bone mineral density in ovariectomized osteoporotic rats. Methods Female SD rats were randomly divided into 4 groups: blank control group (group A), model group (group B), cell therapy group (group C), and Raloxifene treatment group (group D). The model was established after ovariectomy. Rats in group C received the transplantation of BMSCs via the tail vein. Rats in group D received the oral treatment of anti-osteoporosis drug (Raloxifene). Results Bone mineral density (BMD) of the lumbar vertebrae and the femur in group B was significantly lower than that in group A (P < 0.01). After BMSCs transplantation, BMD in group C was improved obviously, and there was significant difference comparing with that in group B (P<0.01). And the BMD in group C was higher than that in group D. Conclusion Transplantation of BMSCs can effectively improve the BMD in ovariectomized osteoporotic rats. These results provide a new method for postmenopausal osteoporosis and experimental evidence for further clinical application of BMSCs transplantation. |
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