| Objective To observe the treatment of sodium hyaluronate combined with salmon calcitonin for knee pain in patients with senile osteoarthritis and osteoporosis. Methods A total of 76 patients, who were diagnosed as osteoarthritis with osteoporosis and had knee pain syndrome, were randomly divided into 2 groups. Forty patients in group A were given intraarticular injection of 2.5ml sodium hyaluronate to the knee, once a week for 5 weeks. Meanwhile they also received an oral administration of 1 Caltrate D tablet per day for 3 months. Thirty-six patients in group B were given a nasal spray of salmon calcitonin, 200IU per day for 3 months. They received the same treatment of both sodium hyaluronate and Caltrate D. Lysholm knee scoring, joint pain intensity evaluation (VAS), and bone mineral density (BMD) detection of the lumbar vertebrae of patients in both groups were performed before and after the treatment. Improvement of other clinical symptoms was recorded. Results Lysholm score of patients in both groups after treatment was significantly improved (P<0.05), but there was no significant difference between the two groups (P>0.05). The situation of knee pain in both groups was improved after the treatment (P<0.05). The effect in group B was better than that in group A (P<0.05). BMD of the lumbar vertebrae in group B increased obviously (P<0.05). Low back pain and other symptoms of systemic osteoporosis alleviated. BMD in group A did not change significantly. The overall patients’ satisfaction to the treatment was worse than that in group B. Conclusion The treatment of sodium hyaluronate combined with salmon calcitonin for knee pain in patients with osteoarthritis and osteoporosis can obtain good effect. With a better function improvement, it can also alleviate knee pain, low back pain, other symptoms of osteoporosis, and can improve the patients' life comprehensively. |