| Bone remodeling, regulated by both biomechanical and non-biomechanical factors, is the major form of bone tissue reconstruction in adults. The state of oxidative stress results from imbalanced generation and elimination of reactive oxygen species (ROS). Under this state, ROS is closely related with the development of osteoporosis and the regulation of bone remodeling as a non-biochemical factor. ROS can impair the ability of mechanical transduction of osteocytes, up-regulate the threshold of bone remodeling. As the result bone mass cannot be maintained by the mechanics stimuli accustomed in bone tissue, and the disuse-mode of bone remodeling occurs. Meanwhile, during the updating of bone mass and the repairing of micro-damage, ROS can inhibit the differentiation of osteoblasts and bone formation, whereas promote the formation of osteoclasts and bone absorption, resulting in a negative bone remodeling. In conclusion, the effect of ROS on bone remodeling results in gradual bone loss and bone micro-architectural deterioration year by year. Osteoporosis exacerbates along with the increase of age. |