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| 5-羟色胺与骨质疏松症 |
| 5-Hydroxytryptamine and osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2013.02.023 |
| 中文关键词: 5 羟色胺 骨质疏松 |
| 英文关键词:5-Hydroxytryptamine Osteoporosis |
| 基金项目:军队中医药科研专项课题重点项目（10ZYZ115） |
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| 中文摘要: |
| 5 羟色胺( 5-Hydroxytryptamine，5-HT) 是一种吲哚胺类化合物。根据其合成部位的不同，而分为外周性5-HT和中枢性5-HT，可以通过两种截然不同的、相反的途径调节骨量。5-HT 相关系统已经展现出其作为新的治疗靶点和改善OP、影响骨代谢的巨大潜力，5-HT受体阻断剂、SERT 拮抗剂等有望成为新的一类有效治疗骨质疏松症的良药。本文就外周性5-HT与骨质疏松症的研究进展作一综述。 |
| 英文摘要: |
| 5-Hydroxytryptamine (5-HT) is a kind of indole amine compounds. According to different locations of synthesis 5-HT can be classified as peripheral 5-HT and central 5-HT, which can regulate the bone mass through two different and contrary pathways. 5-HT related system has showed tremendous potency in new treatment target, improving osteoporosis, and affecting bone metabolism. 5-HT receptor blockers and SERT antagonists are expected to be new drugs for the treatment of osteoporosis. This paper reviews the research progress of peripheral 5-HT and osteoporosis. |
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