|
| 血清中Sclerostin、RANKL及OPG在老年股骨转子间骨折早期的含量改变及其临床意义 |
| Changes of serum sclerostin, RANKL, and OPG at the early stage of femoral intertrochanteric fractures in senile patients and their clinical significance |
| |
| DOI： |
| 中文关键词: Sclerostin RA N KL OPG 老年骨折 骨质疏松 |
| 英文关键词:Sclerostin RA N KL OPG Senile fracture osteoporosis |
| 基金项目:2011年广东省自然科学基金项目（S2011010003333) |
|
| 摘要点击次数: 1209 |
| 全文下载次数: 961 |
| 中文摘要: |
| 目的观察正常成年男女、老年男女及低外力作用下发生髋部骨折的老年男女血清中 sderostin、RANKL及OPG的含量变化并分析其临床意义。方法收集正常成年男女、老年男女及在 2010年10月至2011年10月我院收治的低外力作用下发生股骨转子间骨折的老年患者血清样本。采用酶联免疫吸附实验（EUSA)检测各血清样本中sclerostin、RANKL及OPG的水平。数据均以均数 士标准差表示。采用SPSS13.0对数据进行统计分析。结果正常成年组（A组）：sclerostin 76.6 ±10. 5 pmol/URANKL 0. 58 ±0. 18 ng/ml'OPG 17. 3 ±4. 6 pmol/1;正常老年组（B 组）：sclerostin 102, 0 土 12.3 pmol/l.RANKLO. 25 ±0. 12 ng/ml,OPG 12. 1 ±3.5 pmol/1;老年骨折组（C 组）：sclerostin 90. 8 土 11.0 pmol/URANKL 0. 23 ±0. 13 ng/ml%0PG 11.7 ±3.5 pmol/1。结论由以上结果经统计分析后得 出，SCler0Stin，RANKL及0PG在不同年龄层次其表达水平具有明显差异，与年龄有相关性在老年骨 折的早期阶段（骨折后3天内）血清中sclerostin的含量已出现显著变化。而RANKL及0PG的含量 在骨折早期阶段并无明显改变。由此我们认为，骨折早期血清sclerostin的水平下降在促进骨折愈合 的过程中可能起到一定作用，通过人为干涉抑制sclerosdn的水平对预防老年髋部骨折可能存在一定 的价值。 |
| 英文摘要: |
| To observe the changes of serum sclerostin, RANKL, and OPG in normal adults, normal senile people, and senile people who had hip fractures with a low external force, and their clinical significance. Methods Serum specimen of normal adults, normal senile patients，and senile people who had femoral intertrochanteric fractures with a low external force from October 2010 to October 2011, were collected. Serum sclerostin, RANKL, and OPG were measured using enzyme-linked immunosorbent assay (ELISA). Results were expressed as mean 土 SE. Statistical analysis was conducted using a SPSS17. 0 software. Results Normal adult group (group A) ： sclerostin (76. 6 ± 10. 5 pmol/1), RANKL (0. 58 ± 0. 18 ng/ml) ’ OPG ( 17. 3 ±4. 6 pmol/1) ； Normal senile group ( group B) ： sclerostin ( 102. 0 ± 12. 3 pmol/1),RANKL (0.25 ±0. 12 ng/ml)，OPG ( 12. 1 ± 3. 5 pmol/1) ； Senile fracture group (group C ) ： sclerostin (90. 8 ± 11. 0 pmol/1)，RANKL (0. 23 ±0. 13 ng/ml)，OPG ( 11. 7 ± 3. 5 pmol/1) . Conclusion According to statistical analysis of above results, expression of sclerostin, RANKL, and OPG is distinctly different at different stage of age, and it is correlated with age. The serum expression of sclerostin has already apparently changed at the early stage of the senile fractures ( within 3 days after fractures). No significant changes are |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|