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| 辛伐他汀对去卵巢大鼠脊椎椎体骨形成功能影响的实验研究 |
| Experimental study of the effect of simvastatin on spinal vertebra osteogenesis in ovariectomized rats |
| 投稿时间：2012-07-18 |
| DOI： |
| 中文关键词: 辛伐他汀 骨形成 去卵巢 骨质疏松 生物力学 |
| 英文关键词:Simvastatin Osteogenesis Ovariectomized Osteoporosis Biomechanics |
| 基金项目:上海市自然科学基金项目（10ZR1417600）；上海教委重点学科建设基金（J50206） |
| 作者 | 单位 | E-mail | | 刘铭 | 上海交通大学医学院附属第九人民医院骨科,上海市骨科内植物重点实验室,上海,200011 | ming_li4717@sina.com | | 吴莉 | 69240部队医院 | | | 朱振安 | 上海交通大学医学院附属第九人民医院骨科,上海市骨科内植物重点实验室,上海,200011 | | | 汤亭亭 | 上海交通大学医学院附属第九人民医院骨科,上海市骨科内植物重点实验室,上海,200011 | | | 郝永强 | 上海交通大学医学院附属第九人民医院骨科,上海市骨科内植物重点实验室,上海,200011 | | | 于志锋 | 上海交通大学医学院附属第九人民医院骨科,上海市骨科内植物重点实验室,上海,200011 | |
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| 中文摘要: |
| 目的 观察辛伐他汀对去卵巢大鼠腰椎椎体骨形成功能的影响，评价辛伐他汀对躯干骨骼的骨质疏松是否具有预防和治疗作用。方法 6月龄雌性SD大鼠60只，每组10只，50只切除双侧卵巢分为剂量组和对照组，另10只作为假手术平行对照组。以不同剂量辛伐他汀（5mg、10mg 、20mg 及40mg /kg/d）灌胃。三个月后分别行腰4椎体的双能X线骨密度测试，周围定量CT（pQCT）纵向扫描和腰5椎体的生物力学压缩测试。结果 （1）骨密度和pQCT扫描值：10mg、20mg剂量组数值较高，但皆无统计学差异。（2）生物力学测试：10mg、40mg剂量组数值较高，但无统计学差异。结论 辛伐他汀10mg/kg/d灌胃组（相当人体口服辛伐他汀12 mg～24mg/天）在多数指标中好于其它剂量组，但未发现明显统计学差异。说明辛伐他汀对去卵巢大鼠的躯干骨骼并不具有明显的骨形成促进作用，即对脊柱椎体的骨质疏松并不具有预防和治疗的作用。 |
| 英文摘要: |
| Objective To investigate the effect of simvastatin on spinal vertebra osteoporosis, and to evaluate the prevention and treatment effect of simvastatin on lumbar vertebra osteoporosis in ovariectomized rats. Methods Sixty 6-month female SD rats were randomly divided into 6 groups (n=10): 1 sham group and 5 bilateral ovariectomized groups, including 4 simvastatin groups and 1 control group. Rats in 4 simvastatin groups received a gavage of simvastatin at doses of 5, 10, 20, and 40 mg/kg/d for 3 months, respectively. Meanwhile, rats in control group and sham group received a gavage of normal saline. Three months later, bone mineral density of the L4 vertebrae was detected using dual-energy X-ray absorptiometry (DEXA), and peri-quantiy CT (pQCT) scanning was performed on the L4 vertebrae. Compression test was also performed on the L5 vertebrae. Results The results acquired from both DXA and pQCT in 10mg and 20mg simvastatin group were higher than those in other groups, but no significant difference was observed. Bone biomechanical values in 10mg and 40mg simvastatin group were better than those in other groups, but with no significant difference. Conclusion Most indicators of rats, which receive a gavage of simvastatin at the dose of 10mg/kg/d, equivalent to 12-24mg/d for human, are higher than those in other groups, but no significant difference is observed. Simvastatin shows no significant promoting effect on spinal vertebra osteogenesis in ovariectomized rats, thus has no significant prevention and treatment effect on spinal vertebra osteoporosis. |
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