| Objective To investigate the correlation between serum lipid level and bone mineral density(BMD) in young and middle-aged patients with type 2 diabetes. Methods 230 young and middle-aged patients with type 2 diabetes were divided into two groups, according to T score: osteoporosis group (T≤-2.5) and non-osteoporosis group (T>-2.5)；the levels of serum total cholesterol(TC)、triglyceride(TG)、high density lipoprotein cholesterol (HDL-C)、low density lipoprotein cholesterol (LDL-C) and BMD and other biochemistry markers such as fasting blood glucose, glycated hemoglobin, blood calcium and phosphoremia, liver and renal function, were determined. the correlation between serum lipids and BMD were analyzed. Results (1) In young and middle-aged patients with type 2 diabetes, BMI is positive correlations with BMD(r= 0.256，p<0.01)，but the age and
HDL-C levels showed significantly negative correlations with BMD(r1= -0.298，p1<0.01；r2= -0.237，p2<0.01)，while there were no relationships among the TC, TG, LDL-C levels and BMD. (2)After adjustment for age and BMI, the associations between HDL-C and BMD remained significant (r=-0.152, p<0.05). Conclusions In young and middle-aged patients with type 2 diabetes, the higher HDL-C maybe related to decreased BMD, the incidence of osteoporosis increases with age but decreases with higher BMI. |