| Objective To investigate the serum levels of non-high density lipoprotein cholesterol (non-HDLC) and alkaline phosphatase (ALP) of population in a university in Guangzhou, and to analyze the inner relationship between two markers combining with atherogenic index of plasma (AIP). Methods Clinical data of 505 people, who attended to physical examination in our hospital from 2011 to 2012, were prospectively studied and analyzed. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected according to standard operating procedures. ALP levels were also detected. And then non-HDLC level was calculated according to the formulae. Non-HDLC levels and ALP levels in different groups were statistically analyzed combining with AIP. The predicating significance of non-HDLC on the evaluation of atherosclerosis and the correlation between ALP and blood lipid metabolism were analyzed. Results The serum levels of both non-HDLC and LDL-C showed no gender difference before 60 years old. But peak value of the serum levels appeared after 60 years old and showed gender difference. Non-HDLC was more closely and stably related to AIP than LDL-C as comparing TC and TG on different levels or without grouping. ALP was positively correlated with non-HDLC in both male and female groups over 60 years old (r=0.520, 0.226, respectively, P<0.001, P<0.05). And only in males over than 60 years old, ALP was positively correlated with AIP (r=0.717, P<0.001). Conclusion Compared with using LDL-C alone, combining with the two indexes, non-HDLC and AIP, can improve the accuracy of atherosclerosis risk evaluation. Blood lipid metabolism is correlated with bone metabolism marker, ALP. |