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| 大豆异黄酮对绝经后妇女骨的影响 |
| Effect of soy isoflavone on bone mineral density in postmenopausal women |
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| DOI：10.3969/j.issn.1006-7108.2013.06.020 |
| 中文关键词: 大豆异黄酮 绝经后妇女 骨密度 |
| 英文关键词:Soy isoflavone Postmenopausal women Bone mineral density |
| 基金项目: |
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| 中文摘要: |
| 目的 从临床角度研究大豆异黄酮对兰州地区绝经后妇女骨的影响。方法 在兰州地区筛选出绝经后妇女60人，随机分为大豆异黄酮组(SIF)和对照组(Control),每人每天服用大豆异黄酮90mg或者同等剂量安慰剂，时间6个月。抽血检测血清碱性磷酸酶和血清钙、磷，超声测定胫骨中段骨密度（BMD）。 结果 血清碱性磷酸酶显著下降（P<0.05），血清钙显著升高（P<0.05），胫骨中段BMD显著升高（P<0.05）。结论 大豆异黄酮可增加绝经后妇女骨密度，减少骨丢失。因而可以预防治疗骨质疏松症。 |
| 英文摘要: |
| Objective To investigate the effect of soy isoflavone on bone mineral density in postmenopausal women. Methods Sixty postmenopausal women were selected in Lanzhou and randomly divided into 2 groups: soy isoflavone group (SIF) and control group (Control). All subjects were given 90 mg/d isofalvone or placebo for 6 months. Serum AKP, calcium, and phosphate were detected. Bone mineral density (BMD) of the middle tibia was measured using ultrasound. Results Serum AKP in SIF group decreased significantly (P<0.05), while serum calcium increased significantly (P<0.05). BMD of the middle tibia increased significantly (P<0.05). Conclusion Soy isoflavone can increase BMD and reduce bone loss in postmenopausal women, thus can be used for prevention and treatment of osteoporosis. |
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