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| 岳阳地区50岁以上人群25经维生素D水平及其与骨密度的关系 |
| Serum level of 25-hydroxyvitamin D and its correlation with bone mineral density in population above 50 years old in Yueyang |
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| DOI：10.3969/j.issn.1006.7108.2013.07.008 |
| 中文关键词: 25经维生素D/25 ( OH) D 维生素D缺乏 维生素D不足 骨密度/BMD |
| 英文关键词:25-hydroxyvitamin D/25(OH)D Vitamin D deficiency Vitamin D insufficiency Bone mineral density/BMD |
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| 中文摘要: |
| 目的 通过测定269名岳阳地区50岁以上人群血清25经维生素D(25(OH)D)和骨密度(BMD)水平，分析岳阳地区50岁以上人群的维生素D ( VitD)状况，并探讨其与BMD的关系。方法 采集受试者的血清后，用电化学发光法测定血清25(OH)D水平，并同时应用双能X线吸收仪测定腰椎及髓部BMD。结果 所有受试者中，VitD严重缺乏者占24. 2 %，缺乏者占45. 0%，不足者占24. 5 %，充足者占6. 3。男、女性受试者的25(OH)D水平、腰椎及髓部的BMD间有统计学差异(P<0.001)，男性高于女性。男性各年龄段间25(OH)D水平及各部位BMD无统计学差异(P=0. 101 ,P = 0. 261 ,0. 055 ,0. 170 ,0. 108 ,0. 051 ) ;女性各年龄段之间25(OH)D水平及腰椎BMD无统计学差异(P = 0. 364 , 0. 063 ) ;髓部BMD有统计学差异(P < 0. 001 )，随着年龄的增长而逐步减低。男性受试者中，不同25(OH)D水平组间股骨颈、转子间区及整髓BMD无统计学差异(P = 0. 076 , 0. 425 , 0. 122 );腰椎、大转子区BMD水平间有统计学差异(P=0. 027 , 0. 017 ) , VitD充足组腰椎BMD高于其他各组(P = 0. 005 , 0. 025 , 0. 009 );不足组、严重缺乏组大转子区BMD高于缺乏组(P = 0. 021, 0. 005 )。女性受试者中，不同25(OH)D水平组各部位BMD均无统计学差异(P = 0. 616 , 0. 739 , 0. 559 ; 0. 608 , 0. 641)。结论 在湖南岳阳地区50岁以上人群存在严重的维生素D缺乏及不足;对于维生素D状况与骨密度之间可能无直接关联，需加大样本量进一步观察。 |
| 英文摘要: |
| Objective To analyze the serum levels of vitamin D in population above 50 years old in Yueyang, and to investigate its correlation with bone mineral density(BMD) by detecting the serum levels of vitamin D and BMD in 269 subjects. Methods The blood of all the subjects was collected. Then serum levels of 25-hydroxyvitamin D(25-OH-D) were measured using electrochemiluminescence immunoassay. BMD of the lumbar vertebrae and the hip was measured using dual-energy X-ray absorptiometry. Results Among all the subjects，the prevalence of vitamin D severe deficiency,deficiency, insufficiency, and sufficiency was 24.2%，45.0%，24.5 %，and 6. 3 %，respectively. The 25(OH ) D level and BMD of the lumbar vertebrae and the hip in men were significantly higher than those in women(P<0. 001)?No significant difference of 25(OH) D levels and BMD values of the lumbar vertebrae and the hip in men among all age groups was observed(P=0. 101，0. 261 , 0. 055 , 0. 170 , 0. 108，and 0. 051，respectively ) . No significant difference of 25(OH)D levels and BMD values of the lumbar vertebrae in women among all age groups was observed(P=0. 364，0. 063).However, with the increase of age，the BMD values of the hip were gradually decreased, with significant difference among different age groups(P<0.001).No significant difference of the BMD values of the femur neck，the intertrochanter, and the total hip among different levels of 25(OH)D in men were observed(P=0. 076 , 0. 425，and 0. 122，respectively ).But there was significant difference of the BMD values between the lumbar vertebrae and the trochanter(P=0. 027, 0. 017). BMD of the lumbar vertebrae in vitamin D sufficiency group was higher than that in other groups(P=0. 005 , 0. 025，and 0. 009，respectively ).BMD of the trochanter in vitamin D severe deficiency and insufficiency group was higher than that in deficiency group(P=0. 021，0. 005)In women，no significant difference of the BMD values of the lumbar vertebrae and the hip among the different levels of 25(OH)D was observed(P=0. 616，0. 739，0. 559，0. 608，and 0. 641，respectively). Concluslon Vitamin D deficiency and insufficiency is a quite serious problem in population above 50 years old in Yueyang, Hunan province. There is no evidence that the serum levels of 25(OH)D are associated with BMD. A larger sample study is needed in the future. |
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