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| 利塞膦酸钠对非骨水泥型全髓关节置换术后早期股骨假体周围骨密度的影响 |
| Effect of risedronate on early postoperative periprosthetic bone mineral density of the proximal femur after cementless total hip arthroplasty |
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| DOI：10.3969/j.issn.1006.7108.2013.07.019 |
| 中文关键词: 利塞膦酸钠 全舰关节置换术 股骨近端假体 股骨近端假体周围骨密度 |
| 英文关键词:Risedronate Total hip arthroplasty Proximal femoral prosthesis Periprosthetic bone mineral density of the proximal femur |
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| 中文摘要: |
| :目的 探讨利塞膦酸钠对非骨水泥型全髓关节置换术后早期股骨假体周围骨密度的影响及治疗作用，以其为临床提供防止假体周围骨丢失和松动的预防措施和处理方法。方法2011年3月~2012年5月于本院行非骨水泥型人工全骸关节置换术中符合纳人标准的患者共26例随机分成利塞膦酸钠组与对照组;试验组术后每日口服利塞膦酸钠5 mg+钙剂600 mg，而对照组仅服用钙剂600 mg;分别于术后1周、3,6个月测定股骨近端各感兴趣区(ROI)的骨密度。结果 获得完整病例24例，术后3,6个月各区骨密度均呈持续下降趋势，和对照组相比，术后3个月利塞膦酸钠组股骨假体(ROI1, ROI7 )的差异有统计学意义(P<0.01)，其余各测量区骨密度2组相比差异无统计学意义(P>0.05)。与对照组相比，术后6个月利塞膦酸钠组股骨假体(ROI1 , ROI7 )的差异有统计学意义(P<0.01)，其余各测量区骨密度2组相比差异无统计学意义(P>0.05)。结论 利塞膦酸钠能够有效的减少非骨水泥型全髓关节置换术后假体周围的骨丢失，从而减缓假体松动，延长假体使用寿命。 |
| 英文摘要: |
| Objective To investigate the effect and therapeutic efficacy of risedronate on early postoperative periprosthetic bone mineral density of the proximal femur, in order to provide preventive method to prevent periprosthetic bone loss and loose. Methods Twenty-six patients, who underwent cementless total hip arthroplasty from March 2011 to May2012 in our hospital and met the inclusion criteria, were included in this study. All the patients were randomly divided into the risedronate group and the control group. Patients in the test group took risedronate sodium 5 mg and calcium 600 mg orally per day, while patients in the control group took calcium 600mg per day only. Bone mineral density of the region of interest (ROI) of the proximal femur was detected at the 1st week, 3rd month, and 6th month after the operation. Results Twenty- four full cases were collected. At the 3rd and the 6th month after the operation, bone mineral density showed a continuous decreasing trend. The bone mineral density of the femoral prosthesis(ROI1，ROI7)in risedronate group at the 3rd month after the operation was significantly different with that in control group(P<0.0 1).The bone mineral density of the rest measurement areas in both groups showed no significant difference(P>0.05).Compared with that in control group, the bone mineral density of the femoral prosthesis(ROI1，ROI7)in risedronate group at the 6th month after the operation showed significant difference(P<0.01).The bone mineral density of the rest measurement areas in both groups showed no significant difference(P>0.05).Conclusion Risedronate can effectively reduce the postoperative periprosthetic bone loss after cementless total hip arthroplasty, thereby slowing the loosening of the prosthesis, extending the service life of the prosthesis. |
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