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| “铁调素-Jak/ Stat通路-骨代谢”相关性研究近况 |
| Research progress of the correlation among hepcidin，Jak/Stat signaling pathway，and bone metabolism |
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| DOI：10.3969/j.issn.1006.7108.2013.07.021 |
| 中文关键词: 铁调素 Jak/Slat 骨代谢 |
| 英文关键词:Hepcidin Jak/Stat Bone metabolism |
| 基金项目:国家自然科学基金资助项目(81273090);江苏省自然科学基金资助项目(BK2012608);苏州市科技基础设施建设计划之高技术研究重点实验室资助项目(SZS201208);苏州市应用基础研究计划之医疗卫生部分资助项目(SYS201002) |
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| 中文摘要: |
| 铁调素又称肝脏抗菌多肽，在铁代谢中有着重要调节作用。近些年，有关铁调素与骨代谢相关的报道也日渐增多，2010年美国Huang提出铁调素防治绝经后骨质疏松症专利，Huang的研究认为铁调素可以促进骨形成；但是，铁调素与骨代谢相互关系的具体机理尚无文献报道。Jak/Slat信号通路是体内细胞活动重要的调节转录通路，广泛参与细胞应激、增殖、分化和凋亡等生理过程。最近，有研究认为“铁调素与Jak/Slat信号通路”相关、" Jak/Slat信号通路与骨代谢”相关，那么，对这些研究文献梳理综述对了解铁调素与骨代谢潜在的关系就显得非常有意义。 |
| 英文摘要: |
| Hepcidin, also known as hepatic antimicrobial polypeptides，plays an important role in iron homeostasis.In recent years, reports about the relationship between hepcidin and bone metabolism have increased. In 2010，Huang presented the patent using hepcid for the treatment of postmenopausal osteoporosis. In his research, hepcidin could promote bone formation. Nevertheless, no literatures about the specific mechanism of interrelation between hepcidin and bone metabolism have been reported. The Jak/Slat signaling pathway is an important pathway in transcription regulating process, which is widely involved in cell stress,proliferation, differentiation，and apoptosis. Recently, reports have demonstrated that hepcidin is related with Jak/Slat signaling pathway, and Jak/Slat signaling pathway is also related with bone metabolism. Thus, it is essential to review these literatures for understanding the potential relationship between hepcidin and bone metabolism. |
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