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| 骨化三醇联合降钙素治疗对膝骨性关节炎的临床疗效 |
| Clinical efficacy of calcitriol combined with calcitonin on the treatment of knee osteoarthritis |
| 投稿时间：2012-11-04 |
| DOI： |
| 中文关键词: 骨关节炎 骨质疏松 骨化三醇 降钙素 |
| 英文关键词:Osteoarthritis Osteoporosis Calcitriol Calcitonin |
| 基金项目:上海市卫生局局级课题项目资助(20124303)；上海市自然科学基金资助（13ZR1439100） |
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| 中文摘要: |
| 目的 探讨骨化三醇联合降钙素治疗对有骨质疏松的老年绝经后女性膝骨性关节炎的治疗疗效.方法 门诊选取绝经后具有骨质疏松的老年女性患者125例,所有的患者均具有膝痛和膝部骨性关节炎,应用Kellgren-Lawrence影像系统评分分级,骨关节炎分类为Ⅰ～Ⅲ级.对这些患者应用肌肉注射降钙素联合口服骨化三醇,并针对患者的关节疼痛予以口服塞来昔布,治疗后3个月、6个月、12个月通过西安大略和麦马斯特大学骨性关节炎指标(WOMAC),简明健康调查量表(SF-36)评分系统评估,以及可视化量表(Visual Analog Scale,VAS)评分系统对患者治疗前后的疗效进行分析.结果 治疗后患者WOMAC疼痛指标和功能障碍的指标均明显下降,而且随观察时间延长,呈逐渐下降趋势,组间比较差异有统计学意义(P＜0.05).治疗后3个月、6个月、12个月VAS评分疼痛指标逐渐下降,塞来昔布用量逐渐减少,差异有统计学意义(P＜0.01).治疗后12个月的SF-36量表的各维度得分均有明显提高(P＜0.01),患者没有明显的不良反应.骨化三醇联合降钙素治疗能有效缓解骨关节炎患者的疼痛,改善患者关节功能,减少塞来昔布的用量.结论 降钙素和骨化三醇的联合治疗不仅对骨质疏松有治疗作用,对骨性关节炎也有重要的治疗作用. |
| 英文摘要: |
| Objective To investigate the efficacy of calcitriol combined with calcitonin on the treatment of knee osteoarthritis in senile postmenopausal women with osteoporosis. Methods One hundred and twenty-five postmenopausal female patients with osteoporosis were selected in the department of outpatients. These patients had knee pain and knee osteoarthritis. According to Kellgren-Lawrence radiographic scoring system, osteoarthritis was graded as I-III grade. All the patients were treated with intramuscular injection of calcitonin combined with oral medication of calcitriol. Patients with knee pain were given oral medication of Celecoxib. At the 3rd, 6th, and 12th month after the treatment, Western Ontario and McMaster Universities (WOMAC) osteoarthritis index, the Short Form 36 (SF-36), and visual analog scale (VAS) were used to analyze the efficacy before and after the treatment. Results After the treatment, WOMAC pain indexes and function indexes decreased significantly. And a decreasing tendency along with the time elongation was observed. The difference between groups was significant (P<0.05). After 3-, 6-, and 12-month treatment, VAS pain indexes decreased gradually, and the dosage of Celecoxib decreased. The difference was significant (P<0.05). After 12-month treatment, SF-36 scores increased significantly (P<0.01). Patients had no obvious side effects. Calcitriol combined with calcitonin could effectively relieve the pain in patients with osteoarthritis, improve the function of knee joint, and reduce the dosage of Celecoxib. Conclusion Calcitonin combined with calcitriol not only has effect on the treatment of osteoporosis, but also has important effect on the treatment of osteoarthritis. |
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