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| 胰岛素样生长因子-1在股骨头坏死治疗中的应用 |
| Application of insulin-like growth factor-1 in the treatment of osteonecrosis of the femoral head |
| 投稿时间：2012-07-31 |
| DOI： |
| 中文关键词: 股骨头坏死 IGF-1 成骨细胞 软骨细胞 |
| 英文关键词:Osteonecrosis of the femoral head IGF-1 Osteoblasts Chondrocytes |
| 基金项目:江西省教育厅科学技术基金项目（JJ11359） |
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| 中文摘要: |
| 股骨头坏死是世界难治性疾病,目前治疗主要依靠外科手段,但效果均并不理想.胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)是一种具有促进血管生成,诱导关节软骨细胞、成骨细胞分化的生长因子.笔者通过检索查阅相关文献,简要介绍了当前对IGF-1的基础研究,重点回顾总结了IGF-1治疗股骨头坏死的理论基础,单独或联合组织工程骨、外科手段、基因整合等方式治疗股骨头坏死的进展,并对其今后的研究方向进行了展望. |
| 英文摘要: |
| Osteonecrosis of the femoral head is a refractory disease worldwide. Currently, surgical treatment is the main method we can rely on, but without satisfying results. Insulin-like growth factor-1 (IGF-1) is a growth factor which can promote angiogenesis, induce the differentiation of articular chondrocytes and osteoblasts. Through retrieving the related articles, this paper briefly introduces the basic research of IGF-1 at present. The paper summarizes mainly on the theory basis of IGF-1 for the treatment of osteonecrosis of the femoral head and the progress on the treatment of osteonecrosis of the femoral head, including single-use or combined-use of tissue engineering bone, surgical treatment, and gene integration. This paper also prospects the research direction in the future. |
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