|
| 老年男性骨质疏松性骨折患者血清25羟维生素D 水平研究 |
| Study of the serum 25-OH vitamin D level in senile male patients with osteoporotic fractures |
| |
| DOI： |
| 中文关键词: 老年男性 骨质疏松性骨折 骨密度 维生素D |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 1083 |
| 全文下载次数: 960 |
| 中文摘要: |
| 目的探讨老年男性性骨质疏松合并骨折血清25羟维生素D的水平。方法选择2011年3月至2013年5月我科住 院的78例患者，包括老年男性骨质疏松性骨折患者38例，年龄76. 78 ±6.47岁，不伴骨折老年男性骨质疏松患者40例，年龄 73. 74 ±5. 09岁。采用美国Norland双光能X线骨密度检测仪对所有患者进行腰椎L244和左侧股骨近端(包括Neck、Troch、 Ward三角区）骨密度测量，并测定身高、体重、血谷丙转氨酶（ALT)、谷草转氨酶(AST)、肌酐(CRE)、尿素氮（BUN)。采用酶 联免疫吸附法测定两组患者血清25羟维生素D，比较两组25羟维生素D水平。结果老年男性骨质疏松性骨折组患者血清 25羟维生素D3(16. 11 ±4.46)ng/ml，较老年男性非骨折骨质疏松患者（18. 73 ±6.47) ng/ml低，差异具有统计学意义（P < 0.05);老年骨质疏松性骨折组患者 ALT(18. 87 ±6. 83) IU/L、AST(20. 75 ±6. 15) IU/L、CRE (70. 92 ± 12. 25 ) umol/L、BUN (5. 75 ± 1. 4 ) mmol/L 与骨质疏松组 ALT( 19. 17 士 10. 24) IU/L、AST( 18. 50 ±4. 56) IU/L、CRE (82. 22 ± 8. 7) umol/L、BUN (6. 2 ± 1. 02) mmol/L相比，差异无统计学意义(P > 0. 05 );老年骨质疏松性骨折患者L24、Neck、Troch、ward ’ s三角区的骨密度分 别为（0.81 ±0.21) g/cm2、（0. 68 ±0.15) g/cm2、（0. 74 ± 0. 63) g/m2、（0. 52 ± 0.15) gLm2 与对照组（0.95 ±0.20) g/cm2、 (0.67±0. 09)g/cm2、（0. 63 ±0. 85)g/cm2、（0.54±0.17)g/cm2 相比较，差异没有统计学意义（P > 0. 05)。结论老年男性骨 质疏松合并骨折患者较未合并骨折骨质疏松患者维生素D缺乏更严重。 |
| 英文摘要: |
| Objective To investigate the serum 25 ( OH) VD3 level in senile male patients with osteoporotic fractures . Methods Seventy -eight patients，who were hospitalized in our department from March 2011 to May 2013，were selected. Among all the patients， 38 senile male patients had osteoporotic fractures with an average age of 76. 78 ± 6. 47 years old，while 40 senile male patients with an average age of 73. 74 ± 5. 09 years old had no fractures. Bone mineral density of L2-— and the left proximal femur (including the Neck， the Troch，and the Ward ’ s triangle) was detected using dual energy X —ay absorptiometry ( DEXA， Norland， USA). The height， weight，ALT，AST， CRE， and BUN were also detected. The serum 25 ( OH) VD3 level was detected using enzyme linked immunosorbent assay (ELISA)， and the serum 25 ( OH) VD3 levels were compared between the 2 groups. Results The serum 25 (OH) VD3 level in osteoporotic fracture group was 16. 11 ±4.46 ng/ml，which was lower than that in non -osteoporotic fracture group (18. 73 ±6. 47 ng/ml)，and the difference was significant (P <0. 05). The levels of ALT，AST，CRE，and BUN in osteoporotic fracture group were 18. 87 ±(5. 83 IU/L，20. 75 ±(5. 15 IU/L，70. 92 士 12. umol/L, and 5. 75 ± 1. 4 mmo^L，respectively，which had no significant difference with those in non -osteoporotic fracture group (19. 17 ±10. 24 IU/L，18. 50 ±4. 56 IU/L，82. 22 ±8. 7 umol/L，and 6. 2 ± 1. 02 mmol/L，respectively ； P > 0. 05). The bone mineral density of L2—，the Neck，the Troch，and the Ward ’ s triangle in osteoporotic fracture group was 0. 81 ± 0. 21 g/cm2，0. 68 ± 0. 15 g/cm2，0. 74 士 0. 63 g/cm2，and 0. 52 ± 0. 15 g/cm2， respectively，which had no significant difference with that in non -osteoporotic fracture group (0. 95 ± 0. 20 g/cm2，0. 67 ± 0. 09 g/ cm2，0. 63 ± 0. 85 g/ cm2，and 0. 54 ± 0. 17 g/ cm2， respectively ； P >0.05). Conclusion Vitamin D deficiency in senile male patients with osteoporotic fractures is more serious than that in senile male patients without osteoporotic fractures . |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |