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| 维汉2型糖尿病女性骨代谢指标对比 及相关影响因素 |
| Comparison of Bone metabolic markers between Uyghur and Han nationalities in Hospitalized type 2 diabetic female patients and investigating their influential factors |
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| DOI： |
| 中文关键词: 2型糖尿病；骨代谢 维族 女性 |
| 英文关键词:type 2 diabetes bone metabolism Uyghur female |
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| 中文摘要: |
| 目的比较住院维汉2型糖尿病女性骨代谢指标，并研究相关影响因素。方法纳人住院的2型糖尿病维汉女性患者 共264人，维吾尔族172人，汉族92人，空腹抽血查碱性磷酸酶(ALP)，骨钙素（BGP)，血钙（Ca)、维生素D3 ( VitD3)，雌二醇 (E2)，血清总睾酮(T)，糖化血蛋白（HbA1C)，测量身高、体重，腹围，并计算BMI。结果维汉两组年龄，病程，绝经情况，E2 及T无统计学差异，P >0.05，而腹围，BMI，HbA1 c，ALP及BGP水平较汉族组高，尸<0. 05，血钙及VitD3水平略低于汉族组，P <0.05。多元线性回归分析中，BGP存在民族差异(P =0.002)，绝经患者的骨钙素水平高于未绝经者(P = 0.003);BMI与骨 钙素的水平呈负相关(P =0. 001)。结论维吾尔族2型糖尿病女性患者的BGP水平较汉族患者略高，无论种族如何，BGP的 水平与BMI呈负相关，绝经后女性的BGP水平显著高于绝经前女性。 |
| 英文摘要: |
| Objective Comparison of Bone metabolic markers between Uyghur and Han nationalities in Hospitalized type 2 diabetic female patients and investigating their influential factors . Method 264 Hospitalized type 2 diabetic female patients were included，and Uyghur was 172，Han was 92. fasting blood samples were tested for alkaline phosphatase ( ALP)，bone gla protein( BGP)，blood calcium (Ca)、vitamin D3 (vitD3 )，estradiol ( E2)，total testosterone (T)，glycosylated hemoglobin ( HbA1C)，and all participants were tested for height，body weight，waist circumference and BMI were calculated . Results age，duration of disease，proportion of menopause，E2 and T had no statistical significance between groups，P >0. 05 ; waist circumference，BMI，HbA1 c，ALP and BGP were higher in Uyghur group，P < 0. 05，however，blood calcium and vitD3 were lower in Uyghur group，P < 0. 05; in multiple linear regression analysis，BGP indicated nationality difference (P = 0. 002) ； BGP in menopause patients was higher than none ^menopause patients ( P = 0. 003 ) ； BMI had negative relation with BGP ( P =0. 001). Conclusion Uyghur type 2 diabetic female patients had higher BGP than Han nationality ； Regardless of nationality，level of BGP was higher in menopause patients than none ^menopause patients and had negative relation with BMI. |
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