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| RANKL/RANK信号途径与类风湿关节炎骨量丢失的相关性 |
| Correlation between the RANKL/RANK signaling pathway and bone loss in rheumatoid arthritis |
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| DOI：10.3969/j.issn.1006-7108.2013.10.024 |
| 中文关键词: 类风湿关节炎 细胞核因子κB受体活化因子配体 骨免疫 骨量丢失 |
| 英文关键词:Rheumatoid arthritis RANKL Osteoimmunology Bone loss |
| 基金项目:上海市科委资助项目（09411967400）；上海市长宁区青年课题项目（20094Q03001） |
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| 中文摘要: |
| 类风湿关节炎（rheumatoid arthritis，RA）是一种慢性全身性自身免疫性疾病，临床上抑制RA患者关节周围及全身的骨量丢失是治疗的关键。研究表明炎症细胞因子（TNF-α、IL-1、IL-7、IL-17等)是刺激导致RA患者骨量丢失的重要介质，破骨细胞是参与骨吸收的主要细胞，RANKL/RANK信号途径是RA炎症导致骨量丢失的主要通路。RANKL/RANK信号途径为以RA为代表的自身免疫性疾病与骨代谢疾病之间建起了一座桥梁，其在免疫系统和破骨细胞发育中的关键作用已经形成了“骨免疫”理论，以更准确的揭示在RA继发骨量丢失的过程中免疫系统与骨代谢系统间复杂的交互作用。本文综述了RA继发骨量丢失与RANKL/RANK信号途径间的相关性。 |
| 英文摘要: |
| Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. The key treatment of RA in clinical work is to inhibit the bone mass loss around the joints and in the whole body in patients with RA. Researches reveal that inflammatory cytokines (TNF-α, IL-1, IL-7, and IL-17) are important mediators leading to bone loss in patients with RA. Osteoclasts are the main cells involved in bone absorption. RANKL/RANK signal pathway is the main pathway leading to bone loss in RA. RANKL/RANK signal pathway is a bridge between autoimmune diseases, which are represented by RA, and bone metabolism diseases. More importantly, osteoimmunology theory has been formed according to its key role in the immune system and osteoclast development, which can reveal the complex interactions between the immune system and bone metabolism in the process of bone loss secondary to RA more accurately. This article reviews the correlation between the bone loss secondary to RA and the RANKL/RANK signal pathway. |
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