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| 糖尿病骨质疏松的细胞及分子机制研究进展 |
| Research progress of cellular and molecular mechanism of osteoporosis in patients with diabetes mellitus |
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| DOI：10.3969/j.issn.1006.7108.2013.11.019 |
| 中文关键词: 糖尿病 骨质疏松 机制 |
| 英文关键词:Diabetes mellitus Osteoporosis Mechanism |
| 基金项目: |
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| 摘要点击次数: 1534 |
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| 中文摘要: |
| 糖尿病患者骨质疏松的发生源于骨代谢状态改变，与胰岛素、胰岛素样生长因子-1(IGF-1)的作用有关。此外，高血糖毒性刺激细胞分泌肿瘤坏死因子α(TNF-α)、巨噬细胞集落刺激因子（MCSF)、核因子kB受体活化因子配体（RANKL)、血管 内皮生长因子-A( VEGF-A)等破骨源性细胞因子也发挥重要作用。 |
| 英文摘要: |
| Osteoporosis in patients with diabetes mellitus originates from the alteration in bone metabolism, which is regulated by insulin and insulin-like growth factor 4 (IGF-1). In addition，the osteoclastogenic mediators，which are secreted by the stimulation of hyperglycemia toxicity，including TNF-α，macrophage colony stimulating factor ( MCSF)，receptor activator of nuclear factor -kB ligand (RANKL)，and vascular endothelial growth factor A ( VEGF-A)，also play an important role in the progress of osteoporosis . |
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