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| 女性血清护骨素和转化生长因子β1与骨丢失率的关系 |
| Relationship between serum levels of OPG and TGF-β1 and bone loss rate in women |
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| DOI： |
| 中文关键词: 护骨素 转化生长因子屮1 骨丢失率 女性 骨质疏松 |
| 英文关键词:Osteoprotegerin TGF-(31 Bone loss rate Women Osteoporosis |
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| 中文摘要: |
| 目的护骨素（OPG)和转化生长因子P1(TGF-P1)与骨代谢密切相关。本研究调查女性血清OPG和TGF~(i1水平与 骨丢失率(BLR)的关系，以及这两种细胞因子对BLR的影响。方法横断面研究465例健康成年女性，年龄35 ~ 80岁。测 量血清OPG和TGF~(i1水平，DXA骨密度仪测量腰椎、髋部和前臂远端的骨密度（BMD)和BLR。结果各骨骼部位BLR与 血清 OPG 呈负相关（r =-0. 122 至-0. 230，P = 0. 007-0. 000)，与血清 TGF~(i1 呈正相关（r = 0. 245 - 0. 365，P = 0. 000)。调 整年龄和BMI后，TGF-P1与腰椎和前臂超远端BLR的偏相关性仍然有显著意义。多元线性回归分析显示，OPG对BLR是一 个负性决定因素，大约可以解释BLR变异的1.4% -3.7% ；TGF-(i1对BLR是一个正性决定因素，可以解释BLR变异的5.3% ~ 13. 3%。结论该研究揭示了成年女性循环中OPG和TGF~(i1水平与骨丢失率的关系，提示TGF~(i1和OPG水平变化与骨 丢失率有关，TGF^1可能是女性骨丢失率的独立决定因素。 |
| 英文摘要: |
| Objective To investigate the relationship between serum levels of OPG and TGF-(31 and bone loss rate (BLR) in women，and to explore the effect of these 2 kinds of cytokines on BLR. Methods A cross-sectional study was performed. A total of 465 healthy adult women，aging from 35 to 80 years old were included in this study. The serum levels of OPG and TGF-(31 were determined. Bone mineral density (BMD) and BLR of the lumbar vertebrae，the hip，and the distal forearm were detected using DXA. Results A negative correlation between BLR of all the parts and the serum level of OPG ( r = -0. 122 to -0. 230，all P =0. 007 - 0. 000) was observed，while a positive correlation between BLR and serum TGF-p1 (r = 0. 245 - 0. 365，all P = 0. 000) existed. After adjusting for age and BMI，the significant correlation between serum TGF-(31 and BLR of the lumbar vertebrae and the ultradistal forearm still existed. Multiple linear regression analysis showed that serum OPG was a negative determinant of BLR， explaining 1. 4 - 3. 7% of BLR variation. Serum TGF-31 was a positive determinant of BLR，which could explain 5. 3 - 13. 3% BLR variation. Conclusion This study has revealed the relationship between serum levels of OPG and TGF-(31 and BLR in adult women，which indicates that the changes of TGF-(31 and OPG levels are associated with BLR，and TGF-31 may be an independent determinant for BLR in women. |
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