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| 不同分期慢性肾脏病患者BMD水平与IGF-1表达的 相关性研究 |
| Study of the correlation between bone mineral density and the expression of IGF4 in patients with chronic kidney diseases at different stages |
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| DOI： |
| 中文关键词: 慢性肾脏病 骨密度 IGF4 |
| 英文关键词:Chronic kidney disease Bone mineral density Insulin-like growth factor |
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| 中文摘要: |
| 目的研究不同分期慢性肾脏病患者血清胰岛素样生长因子4( IGF4)的表达与骨密度（BMD)的相关性。方法选 取CKD2 ~5期患者各25例，应用DEXA骨密度仪测定14腰椎前后位丽D和T值，检测血清IGF4水平及其他相关生化指 标的表达。结果CKD5期患者丽D和T值与体检人群有明显差异(P <0.05)，血清IGF4值显著减少(P <0. 01)，血清甲状 旁腺激素（iPTH)及碱性磷酸酶(ALP)明显增高(P < 0. 01)，且血清IGF4水平与BMD呈正相关（r = 0. 6"73)。结论BMD测 定敏感性较高，是目前早期诊断肾性骨病的较好方法;血清IGF4值不仅可反应骨转换水平高低，而且与慢性肾脏病5期患者 BMD的变化相平行，对CKD患者肾性骨病早期诊治和严重程度的判断中亦具有重要临床价值。 |
| 英文摘要: |
| Objective To investigate the correlation between bone mineral density (BMD) and the expression of insulin-like growth factor-L (IGF4) in patients with chronic kidney diseases (CKD) of the different stages. Methods Twenty--ive patients with each stage of CKD (stage 2--) were selected. BMD and the T value of the lumbar vertebrae (L1-L4) at the anteroposterior position were detected using DEXA. The serum levels of IGF-- and other related biochemical indexes including intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) were also detected. Results BMD and the T values in patients with stage 5 CKD had significant difference to that in healthy controls (P < 0. 05). The serum level of IGF-- decreased significantly compared with that in healthy controls (P < 0. 01)，while the serum levels of iPTH and ALP increased significantly (P < 0. 05). The serum level of IGF-- was positively correlated with BMD in patients with stage 5 CKD. Conclusion The detection of BMD has high sensitivity，which is a good diagnostic method for the diagnosis of renal osteopathy at the early stage. The serum level of IGF-- can reflect the level of bone turnover，and parallels with the changes of BMD in patients with stage 5 CKD，showing important clinical value in both the early diagnosis and treatment of renal osteopathy in patients with CKD and the evaluation of the severity of the diseases. |
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