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| 维生素D与2型糖尿病防治的相关性研究 |
| Correlation between vitamin D and the primary prevention of type 2 diabetes |
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| DOI： |
| 中文关键词: 维生素D 糖尿病防治 胰岛素抵抗 胰岛P细胞功能 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 目的观察初诊中青年男性2型糖尿病(T2DM)患者维生素D(25~( OH) D3)水平与胰岛素抵抗及胰岛早期分泌功能 之间的关系，探讨与糖尿病(DM)防治的相关性。方法随机选取初诊中青年男性2型糖尿病患者86名为糖尿病组，健康中 青年男性58名为对照组(NC)，测定25彳OH) D3、糖化血红蛋白浓度（HbA^ )、空腹血糖（FBG)、甘油三酯（TG)、总胆固醇 (TC)、高密度脂蛋白胆固醇(HDL-])及低密度脂蛋白胆固醇(LDL-])，并同期进行精氨酸满岛素兴奋试验。结果①糖尿 病组25彳OH) D3、胰岛P细胞功能指数(HOMA中）和精氨酸满岛素兴奋试验6min胰岛素均低于对照组（P < 0. 05)，而TG、 FPG、HbA1c、胰岛素抵抗指数（HOMA^IR)、SPB均高于对照组(P <0. 01)。②单因素方差分析显示糖尿病家族史对25彳OH) D3水平有影响(P <0.05);对照组无糖尿病家族史与其他各组比较均有统计学意义(P <0.01)，余各组间差别无显著性意义； 对照组无糖尿病家族史受试者的25彳OH) D3水平最高，糖尿病组有糖尿病家族史受试者25彳OH) D3水平最低（P < 0. 01)。 ③相关分析显示25彳OH) D3与HbA^、BMI和HOMA4R呈负相关(P < 0. 05);与胰岛素分泌的峰值倍数呈正相关;调整BMI 后25< OH) D3与HOMA中呈正相关(P <0. 05)。结论中青年糖尿病患者普遍存在维生素D缺乏，尤其有糖尿病家族史者 下降明显，维生素D水平影响胰岛素抵抗及胰岛素早期分泌功能，补充维生素D可能成为糖尿病防治的手段之一。 |
| 英文摘要: |
| Objective To observe the relationship between vitamin D (25— OH) D3) level and insulin resistance and the early secretary function of pancreatic cells in young and middle-aged men with newly diagnosed type 2 diabetes，and to explore its correlation with the primary prevention of diabetes. Methods Eight-six young and middle—ged men，who were newly diagnosed with type 2 diabetes，were randomly selected into the diabetes group. And 58 healthy young and middle-aged men were included in the control group. The serum levels of 25— OH) D3，glycated hemoglobin (HbA1c)，fasting blood glucose (FBG)，triglycerides (TG)，total cholesterol (TC)，high density lipoprotein cholesterol (HDL-C)，and low-density lipoprotein cholesterol (LDL-C) were detected. The arginine-insulin stimulation test was performed simultaneously. Results The 25 - OH) D3 level，pancreatic islet p cell function index (HOMA--)，and the insulin level at the 6 th minute after arginine-insulin stimulation test in the diabetes group were lower than those in the control group (P < 0. 05)，while the levels of TG，FPG，and HbA1c，insulin resistance index (HOMA-IR)，and SPB were higher than those in the control group (P <0.01). The univariate analysis of variance showed that the family history of diabetes could influence the 25- OH) D3 level (p < 0. 05). In control group，those without a family history of diabetes were statistically significant comparing to the other groups (P <0. 01)，while no significant difference was observed between other groups. The 25- OH) D3 level of the subjects without a family history of diabetes in control group was the highest， and the 25- OH) D3 level of the subjects with a family history of diabetes in diabetes group was the lowest (P <0.01). The correlation analysis showed that 25- OH) D3 level was negatively correlated with HbA1c，BMI，and HOMA-IR (p <0. 05)，while positively correlated with the insulin secretion peak multiples. After adjusting for BMI，25- OH) D3 was positively correlated with HOMA-P ( P <0.05). Conclusion The deficiency of vitamin D in young and middle-aged patients with diabetes exists |
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