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| Wnt/P-catenin信号通路及与之相关骨质疏松药物研究 |
| Wnt/P-catenin signaling pathway and the research of osteoporosis-associated drugs |
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| DOI： |
| 中文关键词: Wnt/p-catenin信号通路 Sclerostin 骨质疏松 药物 |
| 英文关键词:Wnt/p-catenin signaling pathway Sclerostin Osteoporosis Drug |
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| 中文摘要: |
| 目的Wntj^atenin信号通路在维持骨组织平衡过程中发挥至关重要的作用，主要通过调节信号通路过程中的三类 抑制物实现,分别为 Sclerostin、Dickkopfs (DKKs)、Secreted frizzled related proteins (SFRPs)。同时,与之相关的促进骨形成的新 药，如Sclerostin单克隆抗体（AMG 785)和DKK1单克隆抗体（RH248),正在进行动物及III期临床试验。本文就Wntj- catenin信号通路的结构及分布，该通路及其调节机制对骨代谢的作用及与之相关的骨质疏松药物研究作一综述。 |
| 英文摘要: |
| Wnt/p-catenin signaling pathway plays an important role in maintaining the balance of bone tissues. which is primarily realized through the regulation of 3 types of inhibitors ： sclerostin. dickkopfs ( DKKs) . and secreted frizzled-related proteins (SFRPs). Moreover. the pathway-targeted drugs that promoting the bone formation. such as sclerostin monoclonal antibody (AMG 785) and DKK1 monoclonal antibody (RH2-L8) . are in animal and Phase H clinical trials. This article reviews the structure and distribution of Wn^p-catenin signaling pathway. its function and mechanism in bone metabolism. and the researches of pathway— targeted drugs. |
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