| Bone metabolism consists of bone formation and bone resorption. The imbalance between them causes osteosclerosis, osteopenia, or even osteoporosis, but the specific signal pathway remains unknown. Current researches reveal that at least 4 signaling pathways participate in bone metabolism: RANKL/RANK/OPG signaling pathway, Wnt/β-catenin signaling pathway, PTH signaling pathway, and PPAR-γ signaling pathway. And the cross-talks exist between pathways. Through the signaling pathways, we can promote the study of bone metabolism and develop new drugs to treat osteoporosis. |