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| 不同年龄糖耐量异常患者骨密度变化的关联研究 |
| The study of the change of bone mineral density in patients with impaired glucose tolerance at different ages |
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| DOI： |
| 中文关键词: 糖耐量异常 骨质疏松 骨密度 血浆葡萄糖 糖化血红蛋白 |
| 英文关键词:Impaired glucose tolerance Osteoporosis Bone mineral density Plasma glucose Glycosylated hemoglobin A1c |
| 基金项目:河北省卫生厅科研基金项目（20100278) |
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| 中文摘要: |
| 目的观察不同年龄段糖耐量异常（IGT)患者骨密度（丽D)的变化及其关联因素。方法在我院进行健康体检的 30?73岁人群，选取290例糖耐量异常者做为实验组，290例年龄、性别相匹配的糖耐量正常（NGT)者做为对照组，对两组骨 密度，空腹血糖、餐后2小时血浆葡萄糖及糖化血红蛋白（HbA1c)水平进行检测，比较两组骨密度、空腹血糖、餐后2小时血 糖、HbA1c变化水平，分析两组间在不同年龄段骨密度的变化及其关联因素。结果IGT组与NGT组的骨密度、餐后2小时 血糖、HbA1c水平比较有统计学意义(P <0. 05)，而两组间空腹血糖比较无统计学意义（P >0. 05)，随着增龄两组间骨密度均 呈下降趋势，其中60岁以上的男性IGT患者BMD明显低于同龄NGT者（P <0. 05)，50岁以上女性IGT患者丽D明显低于 同龄NGT者（P <0.05)。结论随着增龄，及餐后2小时血糖的影响，糖耐量异常患者较糖耐量正常患者更易发生骨质疏 松，且有性别差异，女性年龄较男性提前。 |
| 英文摘要: |
| Objective To observe the change of bone mineral density (BMD) and its associated factors in patients with impaired glucose tolerance (IGT) at different ages. Methods A total of 290 patients with impaired glucose tolerance (IGT) were enrolled as experimental group. They were selected from the people aged from 30 to 73 years old，who came to our hospital for health examination. And 290 people with normal glucose tolerance (NGT) were selected as control group according to age and gender match-up. BMD，fasting plasma glucose (FPG)，2-hr postprandial plasma glucose，and glycosylated hemoglobin (HbA1c) were detected. The changes of BMD，FPG，2-hr postprandial plasma glucose，and HbA1c were compared between the two groups. Further analysis of the change of BMD and its associated factors in patients at different ages between the two groups was performed. Results The difference of BMD，2-hr postprandial plasma glucose，and the level of HbA1c was statistically significant between IGT group and NGT group (P <0. 05). No significant difference of FPG between two groups was observed (P >0.05). Furthermore，BMD showed a decrease trend along with the increase of age in two groups. Among the tested males over 60 years old，BMD in IGT patients was significantly lower than that in NGT patients (P < 0. 05). Similarly，among the tested females over 50 years old，BMD in IGT patients was also significantly lower than that in NGT patients (P <0.05). Conclusion With the increase of age and the influence of 2-hr postprandial plasma glucose，patients with IGT are more likely to have osteoporosis than patients with NGT. And the difference between genders also exists. The occurrence of osteoporosis in females is much earlier than that in males. |
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